Antimicrobial activity of Pterogyne nitens Tul., Fabaceae, against opportunistic fungi

As part of our ongoing research on antifungal agents from Brazilian flora, eight extracts and twelve fractions from Pterogyne nitens Tul., Fabaceae, were screened for antimicrobial activity against four opportunistic fungi species (Candida albicans, Candida krusei, Candida parapsilosis and Cryptococcus neoformans) using a broth microdilution method. The present investigation reveals that P. nitens extracts and fractions were more effective against C. krusei and C. parapsilosis than against C. neoformans. The growth of C. albicans was moderately affected by all tested extracts and fractions. The strongest effects were observed for n-butanol fractions from branches (MIC = 15.6 μg/mL) and roots (MIC = 31.2 μg/mL) against C. krusei. Additionally, the chromatographic fractionation of the n-butanol fraction from branches afforded four guanidine alkaloids; N-1,N-2,N-3-triisopentenylguanidine (1), described for the first time in the Fabaceae family, and nitensidines A-C (2-4), which showed moderate activity towards C. krusei (MIC = 62.5 μg/mL) and C. parapsilosis (MIC = 31.2 μg/mL).

Bibliographic Details

Main Authors:	Regasini,Luis Octávio, Pivatto,Marcos, Scorzoni,Liliana, Benaducci,Tatiane, Fusco-Almeida,Ana Marisa, Giannini,Maria José Soares Mendes, Barreiro,Eliezer Jesus, Siva,Dulce Helena Siqueira, Bolzani,Vanderlan da Silva
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Farmacognosia 2010
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000500009
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