Ankle Osteoarthritis

Abstract Osteoarthritis (OA) is characterized by a chronic, progressive and irreversible degradation of the joint surface associated with joint inflammation. The main etiology of ankle OA is post-traumatic and its prevalence is higher among young and obese people. Despite advances in the treatment of fractures around the ankle, the overall risk of developing posttraumatic ankle OA after 20 years is almost 40%, especially in Weber type B and C bimalleolar fractures and in fractures involving the posterior tibial border. In talus fractures, this prevalence approaches 100%, depending on the severity of the lesion and the time of follow-up. In this context, the current understanding of the molecular signaling pathways involved in senescence and chondrocyte apoptosis is fundamental. The treatment of ankle OA is staged and guided by the classification systems and local and patient conditions. The main problems are the limited ability to regenerate articular cartilage, low blood supply, and a shortage of progenitor stem cells. The present update summarizes recent scientific evidence of post-traumatic ankle OA with a major focus on changes of the synovia, cartilage and synovial fluid; as well as the epidemiology, pathophysiology, clinical implications, treatment options and potential targets for therapeutic agents.

Bibliographic Details

Main Authors:	Godoy-Santos,Alexandre Leme, Fonseca,Lucas Furtado, Cesar Netto,Cesar de, Giordano,Vincenzo, Valderrabano,Victor, Rammelt,Stefan
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Ortopedia e Traumatologia 2021
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162021000600689
Tags:	Add Tag No Tags, Be the first to tag this record!