The evolution of pathogenic trypanosomes

In the absence of a fossil record, the evolution of protozoa has until recently largely remained a matter for speculation. However, advances in molecular methods and phylogenetic analysis are now allowing interpretation of the "history written in the genes". This review focuses on recent progress in reconstruction of trypanosome phylogeny based on molecular data from ribosomal RNA, the miniexon and protein-coding genes. Sufficient data have now been gathered to demonstrate unequivocally that trypanosomes are monophyletic; the phylogenetic trees derived can serve as a framework to reinterpret the biology, taxonomy and present day distribution of trypanosome species, providing insights into the coevolution of trypanosomes with their vertebrate hosts and vectors. Different methods of dating the divergence of trypanosome lineages give rise to radically different evolutionary scenarios and these are reviewed. In particular, the use of one such biogeographically based approach provides new insights into the coevolution of the pathogens, Trypanosoma brucei and Trypanosoma cruzi, with their human hosts and the history of the diseases with which they are associated.

Bibliographic Details

Main Authors:	Stevens,Jamie R., Gibson,Wendy C.
Format:	Digital revista
Language:	English
Published:	Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz 1999
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X1999000400002
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