Pharmacokinetics of sodium meclofenamate in pre-ruminant cattle
The pharmacokinetic profile of sodium meclofenamate, a non-steroidal antiinflammatory drug, was determined in six pre-ruminant calves after intravenous and intramuscular administration at a dose of 2.2mg/kg of body weight. Meclofenamate concentrations were measured using a high performance liquid chromatography assay. The pharmacokinetics of sodium meclofenamate after intravenous and intramuscular administration to calves were characterised by a rapid distribution phase (t½alpha ), 15.45± 4.85min and 23.14± 7.24min for the intravenous and intramuscular administration, respectively, followed by a longer elimination phase (t½beta ) after intramuscular treatment (17.55± 6.52h.). The apparent volume of distribution (Vd) of the drug after intravenous administration was moderate (0.72± 0.12l/kg), and high (3.51± 1.05l/kg) after intramuscular administration. This can be explained by the flip-flop effect or by enterohepatic shunting. The bioavailability achieved after intramuscular administration was 61%.
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Universidade Federal de Minas Gerais, Escola de Veterinária
2004
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oai:scielo:S0102-093520040006000012005-03-04Pharmacokinetics of sodium meclofenamate in pre-ruminant cattlePicco,E.J.Diaz David,D.C.Encinas,T.Rubio,M.R.Boggio,J.C. calf sodium meclofenamate pharmacokinetic pre-ruminant The pharmacokinetic profile of sodium meclofenamate, a non-steroidal antiinflammatory drug, was determined in six pre-ruminant calves after intravenous and intramuscular administration at a dose of 2.2mg/kg of body weight. Meclofenamate concentrations were measured using a high performance liquid chromatography assay. The pharmacokinetics of sodium meclofenamate after intravenous and intramuscular administration to calves were characterised by a rapid distribution phase (t½alpha ), 15.45± 4.85min and 23.14± 7.24min for the intravenous and intramuscular administration, respectively, followed by a longer elimination phase (t½beta ) after intramuscular treatment (17.55± 6.52h.). The apparent volume of distribution (Vd) of the drug after intravenous administration was moderate (0.72± 0.12l/kg), and high (3.51± 1.05l/kg) after intramuscular administration. This can be explained by the flip-flop effect or by enterohepatic shunting. The bioavailability achieved after intramuscular administration was 61%.info:eu-repo/semantics/openAccessUniversidade Federal de Minas Gerais, Escola de VeterináriaArquivo Brasileiro de Medicina Veterinária e Zootecnia v.56 n.6 20042004-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352004000600001en10.1590/S0102-09352004000600001 |
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Picco,E.J. Diaz David,D.C. Encinas,T. Rubio,M.R. Boggio,J.C. |
spellingShingle |
Picco,E.J. Diaz David,D.C. Encinas,T. Rubio,M.R. Boggio,J.C. Pharmacokinetics of sodium meclofenamate in pre-ruminant cattle |
author_facet |
Picco,E.J. Diaz David,D.C. Encinas,T. Rubio,M.R. Boggio,J.C. |
author_sort |
Picco,E.J. |
title |
Pharmacokinetics of sodium meclofenamate in pre-ruminant cattle |
title_short |
Pharmacokinetics of sodium meclofenamate in pre-ruminant cattle |
title_full |
Pharmacokinetics of sodium meclofenamate in pre-ruminant cattle |
title_fullStr |
Pharmacokinetics of sodium meclofenamate in pre-ruminant cattle |
title_full_unstemmed |
Pharmacokinetics of sodium meclofenamate in pre-ruminant cattle |
title_sort |
pharmacokinetics of sodium meclofenamate in pre-ruminant cattle |
description |
The pharmacokinetic profile of sodium meclofenamate, a non-steroidal antiinflammatory drug, was determined in six pre-ruminant calves after intravenous and intramuscular administration at a dose of 2.2mg/kg of body weight. Meclofenamate concentrations were measured using a high performance liquid chromatography assay. The pharmacokinetics of sodium meclofenamate after intravenous and intramuscular administration to calves were characterised by a rapid distribution phase (t½alpha ), 15.45± 4.85min and 23.14± 7.24min for the intravenous and intramuscular administration, respectively, followed by a longer elimination phase (t½beta ) after intramuscular treatment (17.55± 6.52h.). The apparent volume of distribution (Vd) of the drug after intravenous administration was moderate (0.72± 0.12l/kg), and high (3.51± 1.05l/kg) after intramuscular administration. This can be explained by the flip-flop effect or by enterohepatic shunting. The bioavailability achieved after intramuscular administration was 61%. |
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Universidade Federal de Minas Gerais, Escola de Veterinária |
publishDate |
2004 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352004000600001 |
work_keys_str_mv |
AT piccoej pharmacokineticsofsodiummeclofenamateinpreruminantcattle AT diazdaviddc pharmacokineticsofsodiummeclofenamateinpreruminantcattle AT encinast pharmacokineticsofsodiummeclofenamateinpreruminantcattle AT rubiomr pharmacokineticsofsodiummeclofenamateinpreruminantcattle AT boggiojc pharmacokineticsofsodiummeclofenamateinpreruminantcattle |
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1756395320813551616 |