Vitamin D and Kidney disease: what we know and what we do not know

Vitamin D and Kidney disease: what we know and what we do not know

Vitamin D deficiency is common in the chronic kidney disease (CKD) population. CKD has been recognized as a significant public health problem and CKD patients are at increased risk of total and cardiovascular morbidity and mortality. There are increasing epidemiological data suggesting that vitamin D deficiency may play a role in overall morbidity and mortality associated with CKD. The vitamin D hormonal system is classically implicated in the regulation of calcium homeostasis and bone metabolism but there is ample evidence to support the claim that extra renal conversion of 25(OH)D to 1.25(OH)2 has significant biological roles beyond those traditionally ascribed to vitamin D. Based on the current state of evidence this review intends to give an update on novel biological and clinical insights with relevance to the steroid hormone vitamin D specifically in patients with kidney disease.

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Main Authors: Inda Filho,Antonio Jose, Melamed,Michal Leora
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Nefrologia 2013
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002013000400012
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spelling oai:scielo:S0101-280020130004000122013-12-19Vitamin D and Kidney disease: what we know and what we do not knowInda Filho,Antonio JoseMelamed,Michal Leora 25-hydroxyvitamin D2 kidney failure chronic vitamin D deficiency Vitamin D deficiency is common in the chronic kidney disease (CKD) population. CKD has been recognized as a significant public health problem and CKD patients are at increased risk of total and cardiovascular morbidity and mortality. There are increasing epidemiological data suggesting that vitamin D deficiency may play a role in overall morbidity and mortality associated with CKD. The vitamin D hormonal system is classically implicated in the regulation of calcium homeostasis and bone metabolism but there is ample evidence to support the claim that extra renal conversion of 25(OH)D to 1.25(OH)2 has significant biological roles beyond those traditionally ascribed to vitamin D. Based on the current state of evidence this review intends to give an update on novel biological and clinical insights with relevance to the steroid hormone vitamin D specifically in patients with kidney disease.info:eu-repo/semantics/openAccessSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology v.35 n.4 20132013-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002013000400012en10.5935/0101-2800.20130051
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Inda Filho,Antonio Jose
Melamed,Michal Leora
spellingShingle Inda Filho,Antonio Jose
Melamed,Michal Leora
Vitamin D and Kidney disease: what we know and what we do not know
author_facet Inda Filho,Antonio Jose
Melamed,Michal Leora
author_sort Inda Filho,Antonio Jose
title Vitamin D and Kidney disease: what we know and what we do not know
title_short Vitamin D and Kidney disease: what we know and what we do not know
title_full Vitamin D and Kidney disease: what we know and what we do not know
title_fullStr Vitamin D and Kidney disease: what we know and what we do not know
title_full_unstemmed Vitamin D and Kidney disease: what we know and what we do not know
title_sort vitamin d and kidney disease: what we know and what we do not know
description Vitamin D deficiency is common in the chronic kidney disease (CKD) population. CKD has been recognized as a significant public health problem and CKD patients are at increased risk of total and cardiovascular morbidity and mortality. There are increasing epidemiological data suggesting that vitamin D deficiency may play a role in overall morbidity and mortality associated with CKD. The vitamin D hormonal system is classically implicated in the regulation of calcium homeostasis and bone metabolism but there is ample evidence to support the claim that extra renal conversion of 25(OH)D to 1.25(OH)2 has significant biological roles beyond those traditionally ascribed to vitamin D. Based on the current state of evidence this review intends to give an update on novel biological and clinical insights with relevance to the steroid hormone vitamin D specifically in patients with kidney disease.
publisher Sociedade Brasileira de Nefrologia
publishDate 2013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002013000400012
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AT melamedmichalleora vitamindandkidneydiseasewhatweknowandwhatwedonotknow
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