The effects of bioactive components in Solanum nigrum against oxidative stress in liver damage
Abstract The present study aimed to evaluate the role of bioactive components in Solanum nigrum fruit, its phytochemical screening, and in vivo antioxidant potential against liver injury. The HPLC analysis of an ethanolic extract of Solanum nigrum fruit revealed the presence of bioactive components that showed its significant in vitro antioxidant activity. Moreover, The Sprague Dawley rats were divided into four groups for in vivo analysis: G1 (negative control), G2 (positive control), G3 (rats receiving standard drug), and G4 (rats receiving Solanum nigrum fruit extract). The Solanum nigrum fruit reduced the level of liver enzymes, and bilirubin. An opposite trend was seen in the case of albumin, catalase, creatinine, and superoxide dismutase. Histology slides also showed the normal cell structure of hepatocytes. Conclusively, Solanum nigrum fruit bioactive components have the ability to reduce oxidative stress.
Main Authors: | , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos
2022
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000101296 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S0101-20612022000101296 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S0101-206120220001012962022-08-30The effects of bioactive components in Solanum nigrum against oxidative stress in liver damageALAM,AmnaSAHAR,AmnaSAMEEN,AyshaFAISAL,Muhammad Naeem bioactive components antioxidant Solanum nigrum liver oxidative stress Abstract The present study aimed to evaluate the role of bioactive components in Solanum nigrum fruit, its phytochemical screening, and in vivo antioxidant potential against liver injury. The HPLC analysis of an ethanolic extract of Solanum nigrum fruit revealed the presence of bioactive components that showed its significant in vitro antioxidant activity. Moreover, The Sprague Dawley rats were divided into four groups for in vivo analysis: G1 (negative control), G2 (positive control), G3 (rats receiving standard drug), and G4 (rats receiving Solanum nigrum fruit extract). The Solanum nigrum fruit reduced the level of liver enzymes, and bilirubin. An opposite trend was seen in the case of albumin, catalase, creatinine, and superoxide dismutase. Histology slides also showed the normal cell structure of hepatocytes. Conclusively, Solanum nigrum fruit bioactive components have the ability to reduce oxidative stress.info:eu-repo/semantics/openAccessSociedade Brasileira de Ciência e Tecnologia de AlimentosFood Science and Technology v.42 20222022-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000101296en10.1590/fst.61822 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
ALAM,Amna SAHAR,Amna SAMEEN,Aysha FAISAL,Muhammad Naeem |
spellingShingle |
ALAM,Amna SAHAR,Amna SAMEEN,Aysha FAISAL,Muhammad Naeem The effects of bioactive components in Solanum nigrum against oxidative stress in liver damage |
author_facet |
ALAM,Amna SAHAR,Amna SAMEEN,Aysha FAISAL,Muhammad Naeem |
author_sort |
ALAM,Amna |
title |
The effects of bioactive components in Solanum nigrum against oxidative stress in liver damage |
title_short |
The effects of bioactive components in Solanum nigrum against oxidative stress in liver damage |
title_full |
The effects of bioactive components in Solanum nigrum against oxidative stress in liver damage |
title_fullStr |
The effects of bioactive components in Solanum nigrum against oxidative stress in liver damage |
title_full_unstemmed |
The effects of bioactive components in Solanum nigrum against oxidative stress in liver damage |
title_sort |
effects of bioactive components in solanum nigrum against oxidative stress in liver damage |
description |
Abstract The present study aimed to evaluate the role of bioactive components in Solanum nigrum fruit, its phytochemical screening, and in vivo antioxidant potential against liver injury. The HPLC analysis of an ethanolic extract of Solanum nigrum fruit revealed the presence of bioactive components that showed its significant in vitro antioxidant activity. Moreover, The Sprague Dawley rats were divided into four groups for in vivo analysis: G1 (negative control), G2 (positive control), G3 (rats receiving standard drug), and G4 (rats receiving Solanum nigrum fruit extract). The Solanum nigrum fruit reduced the level of liver enzymes, and bilirubin. An opposite trend was seen in the case of albumin, catalase, creatinine, and superoxide dismutase. Histology slides also showed the normal cell structure of hepatocytes. Conclusively, Solanum nigrum fruit bioactive components have the ability to reduce oxidative stress. |
publisher |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
publishDate |
2022 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000101296 |
work_keys_str_mv |
AT alamamna theeffectsofbioactivecomponentsinsolanumnigrumagainstoxidativestressinliverdamage AT saharamna theeffectsofbioactivecomponentsinsolanumnigrumagainstoxidativestressinliverdamage AT sameenaysha theeffectsofbioactivecomponentsinsolanumnigrumagainstoxidativestressinliverdamage AT faisalmuhammadnaeem theeffectsofbioactivecomponentsinsolanumnigrumagainstoxidativestressinliverdamage AT alamamna effectsofbioactivecomponentsinsolanumnigrumagainstoxidativestressinliverdamage AT saharamna effectsofbioactivecomponentsinsolanumnigrumagainstoxidativestressinliverdamage AT sameenaysha effectsofbioactivecomponentsinsolanumnigrumagainstoxidativestressinliverdamage AT faisalmuhammadnaeem effectsofbioactivecomponentsinsolanumnigrumagainstoxidativestressinliverdamage |
_version_ |
1756392506006700032 |