Extraction of lycopene from tomato pomace and its protective effects on renal injury in diabetic rats
Abstract The aim of this study was to investigate the protective effects of lycopene from tomato pomace on renal injury in diabetic rats. Lycopene was extracted from tomato pomace. The rats were divided into control, model and 10, 20 and mg/kg lycopene groups. The diabetic nephropathy model was constructed in the latter four groups. Then, the latter three groups were treated with 10, 20 and mg/kg lycopene, respectively. After four weeks of treatment, compared with the model group, in 20 and 40 mg/kg lycopene groups the serum fasting plasma glucose level was decreased (P < 0.05), the fasting insulin level was increased (P < 0.05), the renal index and 24-h urinary protein level were decreased (P < 0.05), the blood urea nitrogen and serum creatinine levels were decreased (P < 0.05), the renal tissue superoxide dismutase and glutathione peroxidase levels were increased (P < 0.05), the renal tissue malondialdehyde level was decreased (P < 0.05), and the serum tumor necrosis factor α, interleukin 6 and hypersensitive C-reactive protein levels were decreased (P < 0.05). In conclusion, lycopene from tomato pomace can alleviate renal injury in diabetic rats. The mechanism may be related to the resistance of oxidative stress and inflammatory response.
Main Authors: | , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos
2022
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100938 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S0101-20612022000100938 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S0101-206120220001009382022-03-10Extraction of lycopene from tomato pomace and its protective effects on renal injury in diabetic ratsXIE,RongZHANG,HepingLIU,XiaohuiLIU,JialiLI,Qinyun lycopene diabetes renal injury oxidative stress inflammatory response Abstract The aim of this study was to investigate the protective effects of lycopene from tomato pomace on renal injury in diabetic rats. Lycopene was extracted from tomato pomace. The rats were divided into control, model and 10, 20 and mg/kg lycopene groups. The diabetic nephropathy model was constructed in the latter four groups. Then, the latter three groups were treated with 10, 20 and mg/kg lycopene, respectively. After four weeks of treatment, compared with the model group, in 20 and 40 mg/kg lycopene groups the serum fasting plasma glucose level was decreased (P < 0.05), the fasting insulin level was increased (P < 0.05), the renal index and 24-h urinary protein level were decreased (P < 0.05), the blood urea nitrogen and serum creatinine levels were decreased (P < 0.05), the renal tissue superoxide dismutase and glutathione peroxidase levels were increased (P < 0.05), the renal tissue malondialdehyde level was decreased (P < 0.05), and the serum tumor necrosis factor α, interleukin 6 and hypersensitive C-reactive protein levels were decreased (P < 0.05). In conclusion, lycopene from tomato pomace can alleviate renal injury in diabetic rats. The mechanism may be related to the resistance of oxidative stress and inflammatory response.info:eu-repo/semantics/openAccessSociedade Brasileira de Ciência e Tecnologia de AlimentosFood Science and Technology v.42 20222022-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100938en10.1590/fst.116621 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
XIE,Rong ZHANG,Heping LIU,Xiaohui LIU,Jiali LI,Qinyun |
spellingShingle |
XIE,Rong ZHANG,Heping LIU,Xiaohui LIU,Jiali LI,Qinyun Extraction of lycopene from tomato pomace and its protective effects on renal injury in diabetic rats |
author_facet |
XIE,Rong ZHANG,Heping LIU,Xiaohui LIU,Jiali LI,Qinyun |
author_sort |
XIE,Rong |
title |
Extraction of lycopene from tomato pomace and its protective effects on renal injury in diabetic rats |
title_short |
Extraction of lycopene from tomato pomace and its protective effects on renal injury in diabetic rats |
title_full |
Extraction of lycopene from tomato pomace and its protective effects on renal injury in diabetic rats |
title_fullStr |
Extraction of lycopene from tomato pomace and its protective effects on renal injury in diabetic rats |
title_full_unstemmed |
Extraction of lycopene from tomato pomace and its protective effects on renal injury in diabetic rats |
title_sort |
extraction of lycopene from tomato pomace and its protective effects on renal injury in diabetic rats |
description |
Abstract The aim of this study was to investigate the protective effects of lycopene from tomato pomace on renal injury in diabetic rats. Lycopene was extracted from tomato pomace. The rats were divided into control, model and 10, 20 and mg/kg lycopene groups. The diabetic nephropathy model was constructed in the latter four groups. Then, the latter three groups were treated with 10, 20 and mg/kg lycopene, respectively. After four weeks of treatment, compared with the model group, in 20 and 40 mg/kg lycopene groups the serum fasting plasma glucose level was decreased (P < 0.05), the fasting insulin level was increased (P < 0.05), the renal index and 24-h urinary protein level were decreased (P < 0.05), the blood urea nitrogen and serum creatinine levels were decreased (P < 0.05), the renal tissue superoxide dismutase and glutathione peroxidase levels were increased (P < 0.05), the renal tissue malondialdehyde level was decreased (P < 0.05), and the serum tumor necrosis factor α, interleukin 6 and hypersensitive C-reactive protein levels were decreased (P < 0.05). In conclusion, lycopene from tomato pomace can alleviate renal injury in diabetic rats. The mechanism may be related to the resistance of oxidative stress and inflammatory response. |
publisher |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
publishDate |
2022 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100938 |
work_keys_str_mv |
AT xierong extractionoflycopenefromtomatopomaceanditsprotectiveeffectsonrenalinjuryindiabeticrats AT zhangheping extractionoflycopenefromtomatopomaceanditsprotectiveeffectsonrenalinjuryindiabeticrats AT liuxiaohui extractionoflycopenefromtomatopomaceanditsprotectiveeffectsonrenalinjuryindiabeticrats AT liujiali extractionoflycopenefromtomatopomaceanditsprotectiveeffectsonrenalinjuryindiabeticrats AT liqinyun extractionoflycopenefromtomatopomaceanditsprotectiveeffectsonrenalinjuryindiabeticrats |
_version_ |
1756392457861332992 |