Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension

Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart failure. Current treatments for PAH are palliative and development of new therapies is necessary. Recent and relevant studies have demonstrated that epigenetic processes may exert key influences on the pathogenesis of PAH and may be promising therapeutic targets in the prevention and/or cure of this condition. The aim of the present mini-review is to summarize the occurrence of epigenetic-based mechanisms in the context of PAH physiopathology, focusing on the roles of DNA methylation, histone post-translational modifications and non-coding RNAs. We also discuss the potential of epigenetic-based therapies for PAH.

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Main Authors: Luna,R.C.P., de Oliveira,Y., Lisboa,J.V.C., Chaves,T.R., de Araújo,T.A.M., de Sousa,E.E., Miranda Neto,M., Pirola,L., Braga,V.A., de Brito Alves,J.L.
Format: Digital revista
Language:English
Published: Associação Brasileira de Divulgação Científica 2018
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200301
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spelling oai:scielo:S0100-879X20180012003012019-03-19Insights on the epigenetic mechanisms underlying pulmonary arterial hypertensionLuna,R.C.P.de Oliveira,Y.Lisboa,J.V.C.Chaves,T.R.de Araújo,T.A.M.de Sousa,E.E.Miranda Neto,M.Pirola,L.Braga,V.A.de Brito Alves,J.L. Epigenetic Pulmonary arterial hypertension DNA Methylation Histone acetylation miRNAs Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart failure. Current treatments for PAH are palliative and development of new therapies is necessary. Recent and relevant studies have demonstrated that epigenetic processes may exert key influences on the pathogenesis of PAH and may be promising therapeutic targets in the prevention and/or cure of this condition. The aim of the present mini-review is to summarize the occurrence of epigenetic-based mechanisms in the context of PAH physiopathology, focusing on the roles of DNA methylation, histone post-translational modifications and non-coding RNAs. We also discuss the potential of epigenetic-based therapies for PAH.info:eu-repo/semantics/openAccessAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research v.51 n.12 20182018-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200301en10.1590/1414-431x20187437
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country Brasil
countrycode BR
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libraryname SciELO
language English
format Digital
author Luna,R.C.P.
de Oliveira,Y.
Lisboa,J.V.C.
Chaves,T.R.
de Araújo,T.A.M.
de Sousa,E.E.
Miranda Neto,M.
Pirola,L.
Braga,V.A.
de Brito Alves,J.L.
spellingShingle Luna,R.C.P.
de Oliveira,Y.
Lisboa,J.V.C.
Chaves,T.R.
de Araújo,T.A.M.
de Sousa,E.E.
Miranda Neto,M.
Pirola,L.
Braga,V.A.
de Brito Alves,J.L.
Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
author_facet Luna,R.C.P.
de Oliveira,Y.
Lisboa,J.V.C.
Chaves,T.R.
de Araújo,T.A.M.
de Sousa,E.E.
Miranda Neto,M.
Pirola,L.
Braga,V.A.
de Brito Alves,J.L.
author_sort Luna,R.C.P.
title Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
title_short Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
title_full Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
title_fullStr Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
title_full_unstemmed Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
title_sort insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
description Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart failure. Current treatments for PAH are palliative and development of new therapies is necessary. Recent and relevant studies have demonstrated that epigenetic processes may exert key influences on the pathogenesis of PAH and may be promising therapeutic targets in the prevention and/or cure of this condition. The aim of the present mini-review is to summarize the occurrence of epigenetic-based mechanisms in the context of PAH physiopathology, focusing on the roles of DNA methylation, histone post-translational modifications and non-coding RNAs. We also discuss the potential of epigenetic-based therapies for PAH.
publisher Associação Brasileira de Divulgação Científica
publishDate 2018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200301
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