Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis
The rate of diagnosis of colonization/infection of the airways with Achromobacter xylosoxidans has increased in cystic fibrosis patients, but its clinical significance is still controversial. This retrospective, case-control study aimed to evaluate the clinical impact of A. xylosoxidans colonization/infection in cystic fibrosis patients. Individuals who were chronically colonized/infected (n=10), intermittently colonized/infected (n=15), and never colonized/infected with A. xylosoxidans (n=18) were retrospectively evaluated during two periods that were 2 years apart. Demographic characteristics, clinical data, lung function, and chronic bacterial co-colonization data were evaluated. Of the total study population, 87% were pediatric patients and 65.1% were female. Individuals chronically colonized/infected with A. xylosoxidans had decreased forced expiratory volume in 1 s (51.7% in the chronic colonization/infection group vs 82.7% in the intermittent colonization/infection group vs 76% in the never colonized/infected group). Compared with the other two groups, the rate of co-colonization with methicillin-resistant Staphylococcus aureus was higher in individuals chronically colonized/infected with A. xylosoxidans (P=0.002). Changes in lung function over 2 years in the three groups were not significant, although a trend toward a greater decrease in lung function was observed in the chronically colonized/infected group. Compared with the other two groups, there was a greater number of annual hospitalizations in patients chronically colonized/infected with A. xylosoxidans (P=0.033). In cystic fibrosis patients, there was an increased frequency of A. xylosoxidans colonization/infection in children, and lung function was reduced in patients who were chronically colonized/infected with A. xylosoxidans. Additionally, there were no differences in clinical outcomes during the 2-year period, except for an increased number of hospitalizations in patients with A. xylosoxidans.
Main Authors: | , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Associação Brasileira de Divulgação Científica
2016
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400703 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S0100-879X2016000400703 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S0100-879X20160004007032016-03-15Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosisFirmida,M.C.Pereira,R.H.V.Silva,E.A.S.R.Marques,E.A.Lopes,A.J. Cystic fibrosis Achromobacter spp. Achromobacter xylosoxidans Microbiology The rate of diagnosis of colonization/infection of the airways with Achromobacter xylosoxidans has increased in cystic fibrosis patients, but its clinical significance is still controversial. This retrospective, case-control study aimed to evaluate the clinical impact of A. xylosoxidans colonization/infection in cystic fibrosis patients. Individuals who were chronically colonized/infected (n=10), intermittently colonized/infected (n=15), and never colonized/infected with A. xylosoxidans (n=18) were retrospectively evaluated during two periods that were 2 years apart. Demographic characteristics, clinical data, lung function, and chronic bacterial co-colonization data were evaluated. Of the total study population, 87% were pediatric patients and 65.1% were female. Individuals chronically colonized/infected with A. xylosoxidans had decreased forced expiratory volume in 1 s (51.7% in the chronic colonization/infection group vs 82.7% in the intermittent colonization/infection group vs 76% in the never colonized/infected group). Compared with the other two groups, the rate of co-colonization with methicillin-resistant Staphylococcus aureus was higher in individuals chronically colonized/infected with A. xylosoxidans (P=0.002). Changes in lung function over 2 years in the three groups were not significant, although a trend toward a greater decrease in lung function was observed in the chronically colonized/infected group. Compared with the other two groups, there was a greater number of annual hospitalizations in patients chronically colonized/infected with A. xylosoxidans (P=0.033). In cystic fibrosis patients, there was an increased frequency of A. xylosoxidans colonization/infection in children, and lung function was reduced in patients who were chronically colonized/infected with A. xylosoxidans. Additionally, there were no differences in clinical outcomes during the 2-year period, except for an increased number of hospitalizations in patients with A. xylosoxidans.info:eu-repo/semantics/openAccessAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research v.49 n.4 20162016-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400703en10.1590/1414-431X20155097 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Firmida,M.C. Pereira,R.H.V. Silva,E.A.S.R. Marques,E.A. Lopes,A.J. |
spellingShingle |
Firmida,M.C. Pereira,R.H.V. Silva,E.A.S.R. Marques,E.A. Lopes,A.J. Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis |
author_facet |
Firmida,M.C. Pereira,R.H.V. Silva,E.A.S.R. Marques,E.A. Lopes,A.J. |
author_sort |
Firmida,M.C. |
title |
Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis |
title_short |
Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis |
title_full |
Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis |
title_fullStr |
Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis |
title_full_unstemmed |
Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis |
title_sort |
clinical impact of achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis |
description |
The rate of diagnosis of colonization/infection of the airways with Achromobacter xylosoxidans has increased in cystic fibrosis patients, but its clinical significance is still controversial. This retrospective, case-control study aimed to evaluate the clinical impact of A. xylosoxidans colonization/infection in cystic fibrosis patients. Individuals who were chronically colonized/infected (n=10), intermittently colonized/infected (n=15), and never colonized/infected with A. xylosoxidans (n=18) were retrospectively evaluated during two periods that were 2 years apart. Demographic characteristics, clinical data, lung function, and chronic bacterial co-colonization data were evaluated. Of the total study population, 87% were pediatric patients and 65.1% were female. Individuals chronically colonized/infected with A. xylosoxidans had decreased forced expiratory volume in 1 s (51.7% in the chronic colonization/infection group vs 82.7% in the intermittent colonization/infection group vs 76% in the never colonized/infected group). Compared with the other two groups, the rate of co-colonization with methicillin-resistant Staphylococcus aureus was higher in individuals chronically colonized/infected with A. xylosoxidans (P=0.002). Changes in lung function over 2 years in the three groups were not significant, although a trend toward a greater decrease in lung function was observed in the chronically colonized/infected group. Compared with the other two groups, there was a greater number of annual hospitalizations in patients chronically colonized/infected with A. xylosoxidans (P=0.033). In cystic fibrosis patients, there was an increased frequency of A. xylosoxidans colonization/infection in children, and lung function was reduced in patients who were chronically colonized/infected with A. xylosoxidans. Additionally, there were no differences in clinical outcomes during the 2-year period, except for an increased number of hospitalizations in patients with A. xylosoxidans. |
publisher |
Associação Brasileira de Divulgação Científica |
publishDate |
2016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400703 |
work_keys_str_mv |
AT firmidamc clinicalimpactofachromobacterxylosoxidanscolonizationinfectioninpatientswithcysticfibrosis AT pereirarhv clinicalimpactofachromobacterxylosoxidanscolonizationinfectioninpatientswithcysticfibrosis AT silvaeasr clinicalimpactofachromobacterxylosoxidanscolonizationinfectioninpatientswithcysticfibrosis AT marquesea clinicalimpactofachromobacterxylosoxidanscolonizationinfectioninpatientswithcysticfibrosis AT lopesaj clinicalimpactofachromobacterxylosoxidanscolonizationinfectioninpatientswithcysticfibrosis |
_version_ |
1756391515426390016 |