Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy
We aimed to evaluate the effectiveness and safety of bismuth-containing quadruple therapy plus postural change after dosing for Helicobacter pylori eradication in gastrectomized patients. We compared 76 gastric stump patients with H. pylori infection (GS group) with 50 non-gastrectomized H. pylori-positive patients who met the treatment indication (controls). The GS group was divided into GS group 1 and GS group 2. All groups were administered bismuth potassium citrate (220 mg), esomeprazole (20 mg), amoxicillin (1.0 g), and furazolidone (100 mg) twice daily for 14 days. GS group 1 maintained a left lateral horizontal position for 30 min after dosing. H. pylori was detected using rapid urease testing and histologic examination of gastric mucosa before and 3 months after therapy. Mucosal histologic manifestations were evaluated using visual analog scales of the updated Sydney System. GS group 1 had a higher prevalence of eradication than the GS group 2 (intention-to-treat [ITT]: P=0.025; per-protocol [PP]: P=0.030), and the control group had a similar prevalence. GS group 2 had a lower prevalence of eradication than controls (ITT: P=0.006; PP: P=0.626). Scores for chronic inflammation and activity declined significantly (P<0.001) 3 months after treatment, whereas those for atrophy and intestinal metaplasia showed no significant change. Prevalence of adverse reactions was similar among groups during therapy (P=0.939). A bismuth-containing quadruple therapy regimen plus postural change after dosing appears to be a relatively safe, effective, economical, and practical method for H. pylori eradication in gastrectomized patients.
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Associação Brasileira de Divulgação Científica
2016
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oai:scielo:S0100-879X20160002007022016-02-01Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomyZhang,F.Bao,Z.J.Shi,D.M.Xiang,P.Xiao,L.Huang,Y.Q.Zhang,G.S.Yin,S.M. Helicobacter pylori Gastrectomy Gastric stump Eradication Efficacy We aimed to evaluate the effectiveness and safety of bismuth-containing quadruple therapy plus postural change after dosing for Helicobacter pylori eradication in gastrectomized patients. We compared 76 gastric stump patients with H. pylori infection (GS group) with 50 non-gastrectomized H. pylori-positive patients who met the treatment indication (controls). The GS group was divided into GS group 1 and GS group 2. All groups were administered bismuth potassium citrate (220 mg), esomeprazole (20 mg), amoxicillin (1.0 g), and furazolidone (100 mg) twice daily for 14 days. GS group 1 maintained a left lateral horizontal position for 30 min after dosing. H. pylori was detected using rapid urease testing and histologic examination of gastric mucosa before and 3 months after therapy. Mucosal histologic manifestations were evaluated using visual analog scales of the updated Sydney System. GS group 1 had a higher prevalence of eradication than the GS group 2 (intention-to-treat [ITT]: P=0.025; per-protocol [PP]: P=0.030), and the control group had a similar prevalence. GS group 2 had a lower prevalence of eradication than controls (ITT: P=0.006; PP: P=0.626). Scores for chronic inflammation and activity declined significantly (P<0.001) 3 months after treatment, whereas those for atrophy and intestinal metaplasia showed no significant change. Prevalence of adverse reactions was similar among groups during therapy (P=0.939). A bismuth-containing quadruple therapy regimen plus postural change after dosing appears to be a relatively safe, effective, economical, and practical method for H. pylori eradication in gastrectomized patients.info:eu-repo/semantics/openAccessAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research v.49 n.2 20162016-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000200702en10.1590/1414-431X20155080 |
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Zhang,F. Bao,Z.J. Shi,D.M. Xiang,P. Xiao,L. Huang,Y.Q. Zhang,G.S. Yin,S.M. |
spellingShingle |
Zhang,F. Bao,Z.J. Shi,D.M. Xiang,P. Xiao,L. Huang,Y.Q. Zhang,G.S. Yin,S.M. Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy |
author_facet |
Zhang,F. Bao,Z.J. Shi,D.M. Xiang,P. Xiao,L. Huang,Y.Q. Zhang,G.S. Yin,S.M. |
author_sort |
Zhang,F. |
title |
Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy |
title_short |
Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy |
title_full |
Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy |
title_fullStr |
Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy |
title_full_unstemmed |
Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy |
title_sort |
efficacy of a quadruple therapy regimen for helicobacter pylori eradication after partial gastrectomy |
description |
We aimed to evaluate the effectiveness and safety of bismuth-containing quadruple therapy plus postural change after dosing for Helicobacter pylori eradication in gastrectomized patients. We compared 76 gastric stump patients with H. pylori infection (GS group) with 50 non-gastrectomized H. pylori-positive patients who met the treatment indication (controls). The GS group was divided into GS group 1 and GS group 2. All groups were administered bismuth potassium citrate (220 mg), esomeprazole (20 mg), amoxicillin (1.0 g), and furazolidone (100 mg) twice daily for 14 days. GS group 1 maintained a left lateral horizontal position for 30 min after dosing. H. pylori was detected using rapid urease testing and histologic examination of gastric mucosa before and 3 months after therapy. Mucosal histologic manifestations were evaluated using visual analog scales of the updated Sydney System. GS group 1 had a higher prevalence of eradication than the GS group 2 (intention-to-treat [ITT]: P=0.025; per-protocol [PP]: P=0.030), and the control group had a similar prevalence. GS group 2 had a lower prevalence of eradication than controls (ITT: P=0.006; PP: P=0.626). Scores for chronic inflammation and activity declined significantly (P<0.001) 3 months after treatment, whereas those for atrophy and intestinal metaplasia showed no significant change. Prevalence of adverse reactions was similar among groups during therapy (P=0.939). A bismuth-containing quadruple therapy regimen plus postural change after dosing appears to be a relatively safe, effective, economical, and practical method for H. pylori eradication in gastrectomized patients. |
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Associação Brasileira de Divulgação Científica |
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2016 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000200702 |
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