Mechanisms of endothelial dysfunction in obesity-associated hypertension
Obesity is strongly associated with high blood pressure, dyslipidemia, and type 2 diabetes. These conditions synergistically increase the risk of cardiovascular events. A number of central and peripheral abnormalities can explain the development or maintenance of high blood pressure in obesity. Of great interest is endothelial dysfunction, considered to be a primary risk factor in the development of hypertension. Additional mechanisms also related to endothelial dysfunction have been proposed to mediate the development of hypertension in obese individuals. These include: increase in both peripheral vasoconstriction and renal tubular sodium reabsorption, increased sympathetic activity and overactivation of both the renin-angiotensin system and the endocannabinoid system and insulin resistance. The discovery of new mechanisms regulating metabolic and vascular function and a better understanding of how vascular function can be influenced by these systems would facilitate the development of new therapies for treatment of obesity-associated hypertension.
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Associação Brasileira de Divulgação Científica
2012
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oai:scielo:S0100-879X20120005000032012-05-04Mechanisms of endothelial dysfunction in obesity-associated hypertensionLobato,N.S.Filgueira,F.P.Akamine,E.H.Tostes,R.C.Carvalho,M.H.C.Fortes,Z.B. Hypertension Obesity Endothelial dysfunction Oxidative stress Renin-angiotensin system Nitric oxide Obesity is strongly associated with high blood pressure, dyslipidemia, and type 2 diabetes. These conditions synergistically increase the risk of cardiovascular events. A number of central and peripheral abnormalities can explain the development or maintenance of high blood pressure in obesity. Of great interest is endothelial dysfunction, considered to be a primary risk factor in the development of hypertension. Additional mechanisms also related to endothelial dysfunction have been proposed to mediate the development of hypertension in obese individuals. These include: increase in both peripheral vasoconstriction and renal tubular sodium reabsorption, increased sympathetic activity and overactivation of both the renin-angiotensin system and the endocannabinoid system and insulin resistance. The discovery of new mechanisms regulating metabolic and vascular function and a better understanding of how vascular function can be influenced by these systems would facilitate the development of new therapies for treatment of obesity-associated hypertension.info:eu-repo/semantics/openAccessAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research v.45 n.5 20122012-05-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000500003en10.1590/S0100-879X2012007500058 |
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Lobato,N.S. Filgueira,F.P. Akamine,E.H. Tostes,R.C. Carvalho,M.H.C. Fortes,Z.B. |
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Lobato,N.S. Filgueira,F.P. Akamine,E.H. Tostes,R.C. Carvalho,M.H.C. Fortes,Z.B. Mechanisms of endothelial dysfunction in obesity-associated hypertension |
author_facet |
Lobato,N.S. Filgueira,F.P. Akamine,E.H. Tostes,R.C. Carvalho,M.H.C. Fortes,Z.B. |
author_sort |
Lobato,N.S. |
title |
Mechanisms of endothelial dysfunction in obesity-associated hypertension |
title_short |
Mechanisms of endothelial dysfunction in obesity-associated hypertension |
title_full |
Mechanisms of endothelial dysfunction in obesity-associated hypertension |
title_fullStr |
Mechanisms of endothelial dysfunction in obesity-associated hypertension |
title_full_unstemmed |
Mechanisms of endothelial dysfunction in obesity-associated hypertension |
title_sort |
mechanisms of endothelial dysfunction in obesity-associated hypertension |
description |
Obesity is strongly associated with high blood pressure, dyslipidemia, and type 2 diabetes. These conditions synergistically increase the risk of cardiovascular events. A number of central and peripheral abnormalities can explain the development or maintenance of high blood pressure in obesity. Of great interest is endothelial dysfunction, considered to be a primary risk factor in the development of hypertension. Additional mechanisms also related to endothelial dysfunction have been proposed to mediate the development of hypertension in obese individuals. These include: increase in both peripheral vasoconstriction and renal tubular sodium reabsorption, increased sympathetic activity and overactivation of both the renin-angiotensin system and the endocannabinoid system and insulin resistance. The discovery of new mechanisms regulating metabolic and vascular function and a better understanding of how vascular function can be influenced by these systems would facilitate the development of new therapies for treatment of obesity-associated hypertension. |
publisher |
Associação Brasileira de Divulgação Científica |
publishDate |
2012 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000500003 |
work_keys_str_mv |
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1756391398882410496 |