Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study
We determined and analyzed risk factors of hepatitis C virus (HCV)-infected Brazilian hemophiliacs according to their virological, clinical and epidemiological characteristics. A cross-sectional and retrospective study of 469 hemophiliacs was carried out at a Brazilian blood center starting in October 1997. The prevalence of HCV infection, HCV genotypes and factors associated with HCV RNA detection was determined. The seroprevalence of anti-HCV antibodies (ELISA-3.0) was 44.6% (209/469). Virological, clinical and epidemiological assessments were completed for 162 positive patients. There were seven (4.3%) anti-HCV seroconversions between October 1992 and October 1997. During the same period, 40.8% of the positive anti-HCV hemophiliacs had abnormal alanine transaminase (ALT) levels. Plasma HCV RNA was detected by nested-RT-PCR in 116 patients (71.6%). RFLP analysis showed the following genotype distribution: HCV-1 in 98 hemophiliacs (84.5%), HCV-3 in ten (8.6%), HCV-4 in three (2.6%), HCV-2 in one (0.9%), and not typeable in four cases (3.4%). Univariate analysis indicated that older age (P = 0.017) and abnormal ALT levels (P = 0.010) were associated with HCV viremia, while the presence of inhibitor antibodies (P = 0.024) and HBsAg (P = 0.007) represented a protective factor against the presence of HCV RNA. These findings may contribute to a better understanding of the relationship between HCV infection and hemophilia.
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Associação Brasileira de Divulgação Científica
2002
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oai:scielo:S0100-879X20020005000122002-05-06Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological studyCarmo,R.A.Oliveira,G.C.Guimarães,M.D.C.Oliveira,M.S.Lima,A.A.Buzek,S.C.Corrêa-Oliveira,R.Rocha,M.O.C. Hepatitis C virus HCV genotypes Hemophilia Chronic liver disease Transfusion Brazil We determined and analyzed risk factors of hepatitis C virus (HCV)-infected Brazilian hemophiliacs according to their virological, clinical and epidemiological characteristics. A cross-sectional and retrospective study of 469 hemophiliacs was carried out at a Brazilian blood center starting in October 1997. The prevalence of HCV infection, HCV genotypes and factors associated with HCV RNA detection was determined. The seroprevalence of anti-HCV antibodies (ELISA-3.0) was 44.6% (209/469). Virological, clinical and epidemiological assessments were completed for 162 positive patients. There were seven (4.3%) anti-HCV seroconversions between October 1992 and October 1997. During the same period, 40.8% of the positive anti-HCV hemophiliacs had abnormal alanine transaminase (ALT) levels. Plasma HCV RNA was detected by nested-RT-PCR in 116 patients (71.6%). RFLP analysis showed the following genotype distribution: HCV-1 in 98 hemophiliacs (84.5%), HCV-3 in ten (8.6%), HCV-4 in three (2.6%), HCV-2 in one (0.9%), and not typeable in four cases (3.4%). Univariate analysis indicated that older age (P = 0.017) and abnormal ALT levels (P = 0.010) were associated with HCV viremia, while the presence of inhibitor antibodies (P = 0.024) and HBsAg (P = 0.007) represented a protective factor against the presence of HCV RNA. These findings may contribute to a better understanding of the relationship between HCV infection and hemophilia.info:eu-repo/semantics/openAccessAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research v.35 n.5 20022002-05-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000500012en10.1590/S0100-879X2002000500012 |
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Carmo,R.A. Oliveira,G.C. Guimarães,M.D.C. Oliveira,M.S. Lima,A.A. Buzek,S.C. Corrêa-Oliveira,R. Rocha,M.O.C. |
spellingShingle |
Carmo,R.A. Oliveira,G.C. Guimarães,M.D.C. Oliveira,M.S. Lima,A.A. Buzek,S.C. Corrêa-Oliveira,R. Rocha,M.O.C. Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study |
author_facet |
Carmo,R.A. Oliveira,G.C. Guimarães,M.D.C. Oliveira,M.S. Lima,A.A. Buzek,S.C. Corrêa-Oliveira,R. Rocha,M.O.C. |
author_sort |
Carmo,R.A. |
title |
Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study |
title_short |
Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study |
title_full |
Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study |
title_fullStr |
Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study |
title_full_unstemmed |
Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study |
title_sort |
hepatitis c virus infection among brazilian hemophiliacs: a virological, clinical and epidemiological study |
description |
We determined and analyzed risk factors of hepatitis C virus (HCV)-infected Brazilian hemophiliacs according to their virological, clinical and epidemiological characteristics. A cross-sectional and retrospective study of 469 hemophiliacs was carried out at a Brazilian blood center starting in October 1997. The prevalence of HCV infection, HCV genotypes and factors associated with HCV RNA detection was determined. The seroprevalence of anti-HCV antibodies (ELISA-3.0) was 44.6% (209/469). Virological, clinical and epidemiological assessments were completed for 162 positive patients. There were seven (4.3%) anti-HCV seroconversions between October 1992 and October 1997. During the same period, 40.8% of the positive anti-HCV hemophiliacs had abnormal alanine transaminase (ALT) levels. Plasma HCV RNA was detected by nested-RT-PCR in 116 patients (71.6%). RFLP analysis showed the following genotype distribution: HCV-1 in 98 hemophiliacs (84.5%), HCV-3 in ten (8.6%), HCV-4 in three (2.6%), HCV-2 in one (0.9%), and not typeable in four cases (3.4%). Univariate analysis indicated that older age (P = 0.017) and abnormal ALT levels (P = 0.010) were associated with HCV viremia, while the presence of inhibitor antibodies (P = 0.024) and HBsAg (P = 0.007) represented a protective factor against the presence of HCV RNA. These findings may contribute to a better understanding of the relationship between HCV infection and hemophilia. |
publisher |
Associação Brasileira de Divulgação Científica |
publishDate |
2002 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000500012 |
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