Increased fetal hemoglobin levels in patients infected with human immunodeficiency virus (HIV1/2)
Fetal hemoglobin was measured in HIV1/2 patients under treatment with combined therapy (zidovudine and a protease inhibitor). A total of 143 patients and 103 normal individuals were investigated by the quantitative method of Betke and the semi-quantitative acid elution method of Kleihauer. In the normal person, hemoglobin F makes up less than 1% and an increase higher than 1.5% was observed in 21.4% of HIV patients by the method of Betke and in 24.8% of HIV-infected patients by the method of Kleihauer. The quantitative biochemical method of Betke showed that the populations were significantly different (two-tailed Mann-Whitney test). The reason for this hemoglobin F increase might be ascribed to the effect of zidovudine or to direct viral action on gamma chain expression. The finding of a higher F cell frequency indicated by the method of Kleihauer rather suggests that there is an increased F cell clone proliferation rather than an increase in hemoglobin F level in every cell.
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Associação Brasileira de Divulgação Científica
2000
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oai:scielo:S0100-879X20000011000082000-10-20Increased fetal hemoglobin levels in patients infected with human immunodeficiency virus (HIV1/2)Poli-Neto,A.Nonoyama,K.Oshiro,M.Ebner-Filho,W.Miguita,K.Medeiros,T.M.D.Watanabe,C.I.Barretto,O.C.O. human immunodeficiency virus HIV1/2 hemoglobin fetal hemoglobin F cells zidovudine Fetal hemoglobin was measured in HIV1/2 patients under treatment with combined therapy (zidovudine and a protease inhibitor). A total of 143 patients and 103 normal individuals were investigated by the quantitative method of Betke and the semi-quantitative acid elution method of Kleihauer. In the normal person, hemoglobin F makes up less than 1% and an increase higher than 1.5% was observed in 21.4% of HIV patients by the method of Betke and in 24.8% of HIV-infected patients by the method of Kleihauer. The quantitative biochemical method of Betke showed that the populations were significantly different (two-tailed Mann-Whitney test). The reason for this hemoglobin F increase might be ascribed to the effect of zidovudine or to direct viral action on gamma chain expression. The finding of a higher F cell frequency indicated by the method of Kleihauer rather suggests that there is an increased F cell clone proliferation rather than an increase in hemoglobin F level in every cell.info:eu-repo/semantics/openAccessAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research v.33 n.11 20002000-11-01info:eu-repo/semantics/othertext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100008en10.1590/S0100-879X2000001100008 |
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Poli-Neto,A. Nonoyama,K. Oshiro,M. Ebner-Filho,W. Miguita,K. Medeiros,T.M.D. Watanabe,C.I. Barretto,O.C.O. |
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Poli-Neto,A. Nonoyama,K. Oshiro,M. Ebner-Filho,W. Miguita,K. Medeiros,T.M.D. Watanabe,C.I. Barretto,O.C.O. Increased fetal hemoglobin levels in patients infected with human immunodeficiency virus (HIV1/2) |
author_facet |
Poli-Neto,A. Nonoyama,K. Oshiro,M. Ebner-Filho,W. Miguita,K. Medeiros,T.M.D. Watanabe,C.I. Barretto,O.C.O. |
author_sort |
Poli-Neto,A. |
title |
Increased fetal hemoglobin levels in patients infected with human immunodeficiency virus (HIV1/2) |
title_short |
Increased fetal hemoglobin levels in patients infected with human immunodeficiency virus (HIV1/2) |
title_full |
Increased fetal hemoglobin levels in patients infected with human immunodeficiency virus (HIV1/2) |
title_fullStr |
Increased fetal hemoglobin levels in patients infected with human immunodeficiency virus (HIV1/2) |
title_full_unstemmed |
Increased fetal hemoglobin levels in patients infected with human immunodeficiency virus (HIV1/2) |
title_sort |
increased fetal hemoglobin levels in patients infected with human immunodeficiency virus (hiv1/2) |
description |
Fetal hemoglobin was measured in HIV1/2 patients under treatment with combined therapy (zidovudine and a protease inhibitor). A total of 143 patients and 103 normal individuals were investigated by the quantitative method of Betke and the semi-quantitative acid elution method of Kleihauer. In the normal person, hemoglobin F makes up less than 1% and an increase higher than 1.5% was observed in 21.4% of HIV patients by the method of Betke and in 24.8% of HIV-infected patients by the method of Kleihauer. The quantitative biochemical method of Betke showed that the populations were significantly different (two-tailed Mann-Whitney test). The reason for this hemoglobin F increase might be ascribed to the effect of zidovudine or to direct viral action on gamma chain expression. The finding of a higher F cell frequency indicated by the method of Kleihauer rather suggests that there is an increased F cell clone proliferation rather than an increase in hemoglobin F level in every cell. |
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Associação Brasileira de Divulgação Científica |
publishDate |
2000 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100008 |
work_keys_str_mv |
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