Fetal hemoglobin levels are related to metabolic control in diabetic subjects
We have investigated the relationship between fetal hemoglobin (HbF) levels and metabolic control in subjects with insulin-dependent (N = 79) and non-insulin-dependent diabetes mellitus (N = 242). HbF and hemoglobin A1c (HbA1c) levels were increased in subjects with type 1 and type 2 diabetes as compared to levels in nondiabetic individuals (P<0.0001), and were significantly higher in type 1 than in type 2 diabetes subjects. Lower levels of HbA1c and HbF were observed in type 2 diabetes subjects treated by diet, intermediate levels in those treated with oral hypoglycemic agents, and higher levels in those treated with insulin. HbF and HbA1c levels were correlated in type 1 diabetes (R2 = 0.57, P<0.0001) and type 2 diabetes (R2 = 0.58, P<0.0001) subjects. Following intense treatment, twelve diabetic patients showed significant improvement both in HbA1c and HbF values. We conclude that increased HbF levels reflect poor metabolic control in subjects with diabetes mellitus.
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Associação Brasileira de Divulgação Científica
1999
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oai:scielo:S0100-879X19990006000051999-06-16Fetal hemoglobin levels are related to metabolic control in diabetic subjectsPardini,V.C.Victória,I.M.N.Pieroni,F.B.Milagres,G.Nascimento,P.D.Velho,G.Purisch,S.Pardini,H. fetal hemoglobin HbA1c glycated hemoglobin diabetes mellitus type 1 diabetes type 2 diabetes We have investigated the relationship between fetal hemoglobin (HbF) levels and metabolic control in subjects with insulin-dependent (N = 79) and non-insulin-dependent diabetes mellitus (N = 242). HbF and hemoglobin A1c (HbA1c) levels were increased in subjects with type 1 and type 2 diabetes as compared to levels in nondiabetic individuals (P<0.0001), and were significantly higher in type 1 than in type 2 diabetes subjects. Lower levels of HbA1c and HbF were observed in type 2 diabetes subjects treated by diet, intermediate levels in those treated with oral hypoglycemic agents, and higher levels in those treated with insulin. HbF and HbA1c levels were correlated in type 1 diabetes (R2 = 0.57, P<0.0001) and type 2 diabetes (R2 = 0.58, P<0.0001) subjects. Following intense treatment, twelve diabetic patients showed significant improvement both in HbA1c and HbF values. We conclude that increased HbF levels reflect poor metabolic control in subjects with diabetes mellitus.info:eu-repo/semantics/openAccessAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research v.32 n.6 19991999-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000600005en10.1590/S0100-879X1999000600005 |
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Pardini,V.C. Victória,I.M.N. Pieroni,F.B. Milagres,G. Nascimento,P.D. Velho,G. Purisch,S. Pardini,H. |
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Pardini,V.C. Victória,I.M.N. Pieroni,F.B. Milagres,G. Nascimento,P.D. Velho,G. Purisch,S. Pardini,H. Fetal hemoglobin levels are related to metabolic control in diabetic subjects |
author_facet |
Pardini,V.C. Victória,I.M.N. Pieroni,F.B. Milagres,G. Nascimento,P.D. Velho,G. Purisch,S. Pardini,H. |
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Pardini,V.C. |
title |
Fetal hemoglobin levels are related to metabolic control in diabetic subjects |
title_short |
Fetal hemoglobin levels are related to metabolic control in diabetic subjects |
title_full |
Fetal hemoglobin levels are related to metabolic control in diabetic subjects |
title_fullStr |
Fetal hemoglobin levels are related to metabolic control in diabetic subjects |
title_full_unstemmed |
Fetal hemoglobin levels are related to metabolic control in diabetic subjects |
title_sort |
fetal hemoglobin levels are related to metabolic control in diabetic subjects |
description |
We have investigated the relationship between fetal hemoglobin (HbF) levels and metabolic control in subjects with insulin-dependent (N = 79) and non-insulin-dependent diabetes mellitus (N = 242). HbF and hemoglobin A1c (HbA1c) levels were increased in subjects with type 1 and type 2 diabetes as compared to levels in nondiabetic individuals (P<0.0001), and were significantly higher in type 1 than in type 2 diabetes subjects. Lower levels of HbA1c and HbF were observed in type 2 diabetes subjects treated by diet, intermediate levels in those treated with oral hypoglycemic agents, and higher levels in those treated with insulin. HbF and HbA1c levels were correlated in type 1 diabetes (R2 = 0.57, P<0.0001) and type 2 diabetes (R2 = 0.58, P<0.0001) subjects. Following intense treatment, twelve diabetic patients showed significant improvement both in HbA1c and HbF values. We conclude that increased HbF levels reflect poor metabolic control in subjects with diabetes mellitus. |
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Associação Brasileira de Divulgação Científica |
publishDate |
1999 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000600005 |
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AT pardinivc fetalhemoglobinlevelsarerelatedtometaboliccontrolindiabeticsubjects AT victoriaimn fetalhemoglobinlevelsarerelatedtometaboliccontrolindiabeticsubjects AT pieronifb fetalhemoglobinlevelsarerelatedtometaboliccontrolindiabeticsubjects AT milagresg fetalhemoglobinlevelsarerelatedtometaboliccontrolindiabeticsubjects AT nascimentopd fetalhemoglobinlevelsarerelatedtometaboliccontrolindiabeticsubjects AT velhog fetalhemoglobinlevelsarerelatedtometaboliccontrolindiabeticsubjects AT purischs fetalhemoglobinlevelsarerelatedtometaboliccontrolindiabeticsubjects AT pardinih fetalhemoglobinlevelsarerelatedtometaboliccontrolindiabeticsubjects |
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1756390940930473984 |