Cellular and matrix interactions during the development of T lymphocytes

Cellular and matrix interactions during the development of T lymphocytes

The thymus contains an extensive extracellular matrix. Although thymocytes express integrins capable of binding to matrix molecules, the functional significance of the matrix for T cell development is uncertain. We have shown that the matrix is associated with thymic fibroblasts which are required for the CD44+ CD25+ stage of double negative (CD4-8-) thymocyte development. The survival of cells at this stage is dependent on IL-7 and we propose that the role of fibroblasts is to present, via the matrix, IL-7 to developing T cells.

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Main Authors: Owen,J.J.T., McLoughlin,D.E., Suniara,R.K., Jenkinson,E.J.
Format: Digital revista
Language:English
Published: Associação Brasileira de Divulgação Científica 1999
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500008
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id oai:scielo:S0100-879X1999000500008
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spelling oai:scielo:S0100-879X19990005000081999-04-27Cellular and matrix interactions during the development of T lymphocytesOwen,J.J.T.McLoughlin,D.E.Suniara,R.K.Jenkinson,E.J. extracellular matrix epithelial cells fibroblasts integrins interleukin-7 thymus The thymus contains an extensive extracellular matrix. Although thymocytes express integrins capable of binding to matrix molecules, the functional significance of the matrix for T cell development is uncertain. We have shown that the matrix is associated with thymic fibroblasts which are required for the CD44+ CD25+ stage of double negative (CD4-8-) thymocyte development. The survival of cells at this stage is dependent on IL-7 and we propose that the role of fibroblasts is to present, via the matrix, IL-7 to developing T cells.info:eu-repo/semantics/openAccessAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research v.32 n.5 19991999-05-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500008en10.1590/S0100-879X1999000500008
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Owen,J.J.T.
McLoughlin,D.E.
Suniara,R.K.
Jenkinson,E.J.
spellingShingle Owen,J.J.T.
McLoughlin,D.E.
Suniara,R.K.
Jenkinson,E.J.
Cellular and matrix interactions during the development of T lymphocytes
author_facet Owen,J.J.T.
McLoughlin,D.E.
Suniara,R.K.
Jenkinson,E.J.
author_sort Owen,J.J.T.
title Cellular and matrix interactions during the development of T lymphocytes
title_short Cellular and matrix interactions during the development of T lymphocytes
title_full Cellular and matrix interactions during the development of T lymphocytes
title_fullStr Cellular and matrix interactions during the development of T lymphocytes
title_full_unstemmed Cellular and matrix interactions during the development of T lymphocytes
title_sort cellular and matrix interactions during the development of t lymphocytes
description The thymus contains an extensive extracellular matrix. Although thymocytes express integrins capable of binding to matrix molecules, the functional significance of the matrix for T cell development is uncertain. We have shown that the matrix is associated with thymic fibroblasts which are required for the CD44+ CD25+ stage of double negative (CD4-8-) thymocyte development. The survival of cells at this stage is dependent on IL-7 and we propose that the role of fibroblasts is to present, via the matrix, IL-7 to developing T cells.
publisher Associação Brasileira de Divulgação Científica
publishDate 1999
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500008
work_keys_str_mv AT owenjjt cellularandmatrixinteractionsduringthedevelopmentoftlymphocytes
AT mcloughlinde cellularandmatrixinteractionsduringthedevelopmentoftlymphocytes
AT suniarark cellularandmatrixinteractionsduringthedevelopmentoftlymphocytes
AT jenkinsonej cellularandmatrixinteractionsduringthedevelopmentoftlymphocytes
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