Spinal cord compression in cattle after the use of an oily vaccine

An outbreak of compressive myelopathy in cattle associated with the improper use of an oil vaccine is described. Neurological signs were observed in 25 out of 3,000 cattle after 60 days of being vaccinated against foot and mouth disease. The clinical picture was characterized by progressive paralysis of the hind limbs, difficulty in standing up, and sternal recumbency during the course of 2-5 months. A filling defect between the L1 and L3 vertebrae was seen through myelography performed in one of the affected animals. A yellow-gray, granular and irregular mass was observed in four necropsied animals involving the spinal nerve roots and epidural space of the lumbar (L1-L4) spinal cord; the mass was associated with a whitish oily fluid. This fluid was also found in association with necrosis of the longissimus dorsi muscle. Microscopic changes in the epidural space, nerve roots, and spinal musculature were similar and consisted of granulomas or pyogranulomas around circular unstained spaces (vacuoles). These spaces were located between areas of severe diffuse hyaline necrosis of muscle fibers and resembled the drops of oil present in the vaccine.

Bibliographic Details

Main Authors:	Ubiali,Daniel Guimarães, Cruz,Raquel Aparecida Sales da, Lana,Marconni Victor da Costa, Meireles,Yara Silva, Néspoli,Pedro Brandini, Souza,Marcos Almeida, Colodel,Edson Moleta, Pescador,Caroline Argenta
Format:	Digital revista
Language:	English
Published:	Colégio Brasileiro de Patologia Animal - CBPA 2011
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2011001100010
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