Preeclampsia as an Inaugural Manifestation of Primary Hyperparathyroidism: A Case Report
Abstract Primary hyperparathyroidism is an endocrine disorder characterized by hypercalcemia and elevated or inappropriately normal levels of parathyroid hormone. The diagnosis is based on a biochemical evaluation, and a neck ultrasound is the first choice during pregnancy to access the parathyroid glands. Manifestations during pregnancy are rare and can be present with life-threatening complications, so the diagnosis is challenging. The conservative treatment is limited, and there is not enough data about its safety and efficacy during pregnancy. Surgery is the only curative treatment, and a parathyroidectomy performed during the second or third trimesters is considered safe. Recently, some authors suggested an association between primary hyperparathyroidism and preeclampsia. We describe a case of preeclampsia with severe features at 27 weeks of gestational age. The severity of the preeclampsiamotivated an early termination of the pregnancy by cesarean section. During the postpartum period, the patient presented life-threatening complications, such as severe hypercalcemia and acute pancreatitis. An ultrasound exam found two parathyroid nodules, suggestive of parathyroid adenomas. The patient recovered after the pharmacological correction of the calcemia levels.
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2020
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oai:scielo:S0100-720320200012008412021-01-06Preeclampsia as an Inaugural Manifestation of Primary Hyperparathyroidism: A Case ReportLeite,Sara DiasOrmonde,Carolina CâmaraOrmonde,Mariana CâmaraRaposo,Joana Teresa Botelho VasconcelosSampaio,Joana Isabel NunesMelo,Bruna Carina da Silva preeclampsia primary hyperparathyroidism hypercalcemia parathyroid adenomas Abstract Primary hyperparathyroidism is an endocrine disorder characterized by hypercalcemia and elevated or inappropriately normal levels of parathyroid hormone. The diagnosis is based on a biochemical evaluation, and a neck ultrasound is the first choice during pregnancy to access the parathyroid glands. Manifestations during pregnancy are rare and can be present with life-threatening complications, so the diagnosis is challenging. The conservative treatment is limited, and there is not enough data about its safety and efficacy during pregnancy. Surgery is the only curative treatment, and a parathyroidectomy performed during the second or third trimesters is considered safe. Recently, some authors suggested an association between primary hyperparathyroidism and preeclampsia. We describe a case of preeclampsia with severe features at 27 weeks of gestational age. The severity of the preeclampsiamotivated an early termination of the pregnancy by cesarean section. During the postpartum period, the patient presented life-threatening complications, such as severe hypercalcemia and acute pancreatitis. An ultrasound exam found two parathyroid nodules, suggestive of parathyroid adenomas. The patient recovered after the pharmacological correction of the calcemia levels.info:eu-repo/semantics/openAccessFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia v.42 n.12 20202020-12-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032020001200841en10.1055/s-0040-1718447 |
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Leite,Sara Dias Ormonde,Carolina Câmara Ormonde,Mariana Câmara Raposo,Joana Teresa Botelho Vasconcelos Sampaio,Joana Isabel Nunes Melo,Bruna Carina da Silva |
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Leite,Sara Dias Ormonde,Carolina Câmara Ormonde,Mariana Câmara Raposo,Joana Teresa Botelho Vasconcelos Sampaio,Joana Isabel Nunes Melo,Bruna Carina da Silva Preeclampsia as an Inaugural Manifestation of Primary Hyperparathyroidism: A Case Report |
author_facet |
Leite,Sara Dias Ormonde,Carolina Câmara Ormonde,Mariana Câmara Raposo,Joana Teresa Botelho Vasconcelos Sampaio,Joana Isabel Nunes Melo,Bruna Carina da Silva |
author_sort |
Leite,Sara Dias |
title |
Preeclampsia as an Inaugural Manifestation of Primary Hyperparathyroidism: A Case Report |
title_short |
Preeclampsia as an Inaugural Manifestation of Primary Hyperparathyroidism: A Case Report |
title_full |
Preeclampsia as an Inaugural Manifestation of Primary Hyperparathyroidism: A Case Report |
title_fullStr |
Preeclampsia as an Inaugural Manifestation of Primary Hyperparathyroidism: A Case Report |
title_full_unstemmed |
Preeclampsia as an Inaugural Manifestation of Primary Hyperparathyroidism: A Case Report |
title_sort |
preeclampsia as an inaugural manifestation of primary hyperparathyroidism: a case report |
description |
Abstract Primary hyperparathyroidism is an endocrine disorder characterized by hypercalcemia and elevated or inappropriately normal levels of parathyroid hormone. The diagnosis is based on a biochemical evaluation, and a neck ultrasound is the first choice during pregnancy to access the parathyroid glands. Manifestations during pregnancy are rare and can be present with life-threatening complications, so the diagnosis is challenging. The conservative treatment is limited, and there is not enough data about its safety and efficacy during pregnancy. Surgery is the only curative treatment, and a parathyroidectomy performed during the second or third trimesters is considered safe. Recently, some authors suggested an association between primary hyperparathyroidism and preeclampsia. We describe a case of preeclampsia with severe features at 27 weeks of gestational age. The severity of the preeclampsiamotivated an early termination of the pregnancy by cesarean section. During the postpartum period, the patient presented life-threatening complications, such as severe hypercalcemia and acute pancreatitis. An ultrasound exam found two parathyroid nodules, suggestive of parathyroid adenomas. The patient recovered after the pharmacological correction of the calcemia levels. |
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
publishDate |
2020 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032020001200841 |
work_keys_str_mv |
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