Inflammatory and nutritional statuses of patients submitted to resection of gastrointestinal tumors

Inflammatory and nutritional statuses of patients submitted to resection of gastrointestinal tumors

ABSTRACT Objective: to evaluate the association between the nutritional and the inflammatory statuses of patients with cancer of the gastrointestinal tract undergoing surgical resection and to identify predictors of mortality in these patients. Methods: we conducted a prospective study of 41 patients with gastrointestinal tract cancer submitted to surgery between October 2012 and December 2014. We evaluated the nutritional status by subjective and objective methods. We assessed the inflammatory response and prognosis using the modified Glasgow Prognostic Score (mGPS), Neutrophil/Lymphocyte Ratio (NLR), Onodera Prognostic Nutritional Index (mPNI), Inflammatory-Nutritional Index (INI) and C-Reactive Protein/Albumin ratio (mPINI). Results: half of the patients were malnourished and 27% were at nutritional risk. There was a positive association between the percentage of weight loss (%WL) and the markers NLR (p=0.047), mPINI (p=0.014) and INI (p=0.015). Serum albumin levels (p=0.015), INI (p=0.026) and mPINI (p=0.026) were significantly associated with the PG-SGA categories. On multivariate analysis, albumin was the only inflammatory marker independently related to death (p=0.004). Conclusion: inflammatory markers were significantly associated with malnutrition, demonstrating that the higher the inflammatory response, the worse the PG-SGA (B and C) scores and the higher the %WL in these patients. However, further studies aimed at improving surgical outcomes and determining the role of these markers as predictors of mortality are required.

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Main Authors: FRUCHTENICHT,ANA VALÉRIA GONÇALVES, POZIOMYCK,ALINE KIRJNER, REIS,AUDREY MACHADO DOS, GALIA,CARLOS ROBERTO, KABKE,GEORGIA BRUM, MOREIRA,LUIS FERNANDO
Format: Digital revista
Language:English
Published: Colégio Brasileiro de Cirurgiões 2018
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912018000200157
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spelling oai:scielo:S0100-699120180002001572018-05-22Inflammatory and nutritional statuses of patients submitted to resection of gastrointestinal tumorsFRUCHTENICHT,ANA VALÉRIA GONÇALVESPOZIOMYCK,ALINE KIRJNERREIS,AUDREY MACHADO DOSGALIA,CARLOS ROBERTOKABKE,GEORGIA BRUMMOREIRA,LUIS FERNANDO Gastrointestinal Neoplasms Nutritional Status Inflammation Mortality. ABSTRACT Objective: to evaluate the association between the nutritional and the inflammatory statuses of patients with cancer of the gastrointestinal tract undergoing surgical resection and to identify predictors of mortality in these patients. Methods: we conducted a prospective study of 41 patients with gastrointestinal tract cancer submitted to surgery between October 2012 and December 2014. We evaluated the nutritional status by subjective and objective methods. We assessed the inflammatory response and prognosis using the modified Glasgow Prognostic Score (mGPS), Neutrophil/Lymphocyte Ratio (NLR), Onodera Prognostic Nutritional Index (mPNI), Inflammatory-Nutritional Index (INI) and C-Reactive Protein/Albumin ratio (mPINI). Results: half of the patients were malnourished and 27% were at nutritional risk. There was a positive association between the percentage of weight loss (%WL) and the markers NLR (p=0.047), mPINI (p=0.014) and INI (p=0.015). Serum albumin levels (p=0.015), INI (p=0.026) and mPINI (p=0.026) were significantly associated with the PG-SGA categories. On multivariate analysis, albumin was the only inflammatory marker independently related to death (p=0.004). Conclusion: inflammatory markers were significantly associated with malnutrition, demonstrating that the higher the inflammatory response, the worse the PG-SGA (B and C) scores and the higher the %WL in these patients. However, further studies aimed at improving surgical outcomes and determining the role of these markers as predictors of mortality are required.info:eu-repo/semantics/openAccessColégio Brasileiro de CirurgiõesRevista do Colégio Brasileiro de Cirurgiões v.45 n.2 20182018-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912018000200157en10.1590/0100-6991e-20181614
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language English
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author FRUCHTENICHT,ANA VALÉRIA GONÇALVES
POZIOMYCK,ALINE KIRJNER
REIS,AUDREY MACHADO DOS
GALIA,CARLOS ROBERTO
KABKE,GEORGIA BRUM
MOREIRA,LUIS FERNANDO
spellingShingle FRUCHTENICHT,ANA VALÉRIA GONÇALVES
POZIOMYCK,ALINE KIRJNER
REIS,AUDREY MACHADO DOS
GALIA,CARLOS ROBERTO
KABKE,GEORGIA BRUM
MOREIRA,LUIS FERNANDO
Inflammatory and nutritional statuses of patients submitted to resection of gastrointestinal tumors
author_facet FRUCHTENICHT,ANA VALÉRIA GONÇALVES
POZIOMYCK,ALINE KIRJNER
REIS,AUDREY MACHADO DOS
GALIA,CARLOS ROBERTO
KABKE,GEORGIA BRUM
MOREIRA,LUIS FERNANDO
author_sort FRUCHTENICHT,ANA VALÉRIA GONÇALVES
title Inflammatory and nutritional statuses of patients submitted to resection of gastrointestinal tumors
title_short Inflammatory and nutritional statuses of patients submitted to resection of gastrointestinal tumors
title_full Inflammatory and nutritional statuses of patients submitted to resection of gastrointestinal tumors
title_fullStr Inflammatory and nutritional statuses of patients submitted to resection of gastrointestinal tumors
title_full_unstemmed Inflammatory and nutritional statuses of patients submitted to resection of gastrointestinal tumors
title_sort inflammatory and nutritional statuses of patients submitted to resection of gastrointestinal tumors
description ABSTRACT Objective: to evaluate the association between the nutritional and the inflammatory statuses of patients with cancer of the gastrointestinal tract undergoing surgical resection and to identify predictors of mortality in these patients. Methods: we conducted a prospective study of 41 patients with gastrointestinal tract cancer submitted to surgery between October 2012 and December 2014. We evaluated the nutritional status by subjective and objective methods. We assessed the inflammatory response and prognosis using the modified Glasgow Prognostic Score (mGPS), Neutrophil/Lymphocyte Ratio (NLR), Onodera Prognostic Nutritional Index (mPNI), Inflammatory-Nutritional Index (INI) and C-Reactive Protein/Albumin ratio (mPINI). Results: half of the patients were malnourished and 27% were at nutritional risk. There was a positive association between the percentage of weight loss (%WL) and the markers NLR (p=0.047), mPINI (p=0.014) and INI (p=0.015). Serum albumin levels (p=0.015), INI (p=0.026) and mPINI (p=0.026) were significantly associated with the PG-SGA categories. On multivariate analysis, albumin was the only inflammatory marker independently related to death (p=0.004). Conclusion: inflammatory markers were significantly associated with malnutrition, demonstrating that the higher the inflammatory response, the worse the PG-SGA (B and C) scores and the higher the %WL in these patients. However, further studies aimed at improving surgical outcomes and determining the role of these markers as predictors of mortality are required.
publisher Colégio Brasileiro de Cirurgiões
publishDate 2018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912018000200157
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