Synthesis, spectroscopic characterization and antibacterial screening of novel n-(benzothiazol-2-yl)ethanamides

Synthesis, spectroscopic characterization and antibacterial screening of novel n-(benzothiazol-2-yl)ethanamides

Synthesis, electronic, infrared, elemental micro analytical studies were carried on N-(benzothiazol-2-yl)trichloroethanamide [4] and N-(benzothiazol-2-yl)chloroethanamide [5]. They were also screened in vitro and in vivo for antibacterial activity. The results indicate that the compounds are very stable and that they show high antibacterial activities against both gram-positive and gram-negative bacteria tested. Both derivatives of 2-aminobenzothiazole were active against the multiresistant bacteria with IZD ranging from 9 -18 mm [5] and 9 - 20mm [4]. From the MIC results it is observed that the [5] derivative produced a better antibacterial activity than the [4] derivative. The lethal concentrations (LC50) of the compounds were also determined. Their solubilities and melting points were also determined.

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Main Authors: Obasi,L.N., Ukoha,P.O., Chah,K.F., Anaga,A.O.
Format: Digital revista
Language:English
Published: Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP 2011
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702011000100001
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spelling oai:scielo:S0100-467020110001000012012-02-29Synthesis, spectroscopic characterization and antibacterial screening of novel n-(benzothiazol-2-yl)ethanamidesObasi,L.N.Ukoha,P.O.Chah,K.F.Anaga,A.O. Lethal Concentration derivatives ethanamides in vitro invivo bioactivity Synthesis, electronic, infrared, elemental micro analytical studies were carried on N-(benzothiazol-2-yl)trichloroethanamide [4] and N-(benzothiazol-2-yl)chloroethanamide [5]. They were also screened in vitro and in vivo for antibacterial activity. The results indicate that the compounds are very stable and that they show high antibacterial activities against both gram-positive and gram-negative bacteria tested. Both derivatives of 2-aminobenzothiazole were active against the multiresistant bacteria with IZD ranging from 9 -18 mm [5] and 9 - 20mm [4]. From the MIC results it is observed that the [5] derivative produced a better antibacterial activity than the [4] derivative. The lethal concentrations (LC50) of the compounds were also determined. Their solubilities and melting points were also determined.info:eu-repo/semantics/openAccessFundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESPEclética Química v.36 n.1 20112011-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702011000100001en10.1590/S0100-46702011000100001
institution SCIELO
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country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Obasi,L.N.
Ukoha,P.O.
Chah,K.F.
Anaga,A.O.
spellingShingle Obasi,L.N.
Ukoha,P.O.
Chah,K.F.
Anaga,A.O.
Synthesis, spectroscopic characterization and antibacterial screening of novel n-(benzothiazol-2-yl)ethanamides
author_facet Obasi,L.N.
Ukoha,P.O.
Chah,K.F.
Anaga,A.O.
author_sort Obasi,L.N.
title Synthesis, spectroscopic characterization and antibacterial screening of novel n-(benzothiazol-2-yl)ethanamides
title_short Synthesis, spectroscopic characterization and antibacterial screening of novel n-(benzothiazol-2-yl)ethanamides
title_full Synthesis, spectroscopic characterization and antibacterial screening of novel n-(benzothiazol-2-yl)ethanamides
title_fullStr Synthesis, spectroscopic characterization and antibacterial screening of novel n-(benzothiazol-2-yl)ethanamides
title_full_unstemmed Synthesis, spectroscopic characterization and antibacterial screening of novel n-(benzothiazol-2-yl)ethanamides
title_sort synthesis, spectroscopic characterization and antibacterial screening of novel n-(benzothiazol-2-yl)ethanamides
description Synthesis, electronic, infrared, elemental micro analytical studies were carried on N-(benzothiazol-2-yl)trichloroethanamide [4] and N-(benzothiazol-2-yl)chloroethanamide [5]. They were also screened in vitro and in vivo for antibacterial activity. The results indicate that the compounds are very stable and that they show high antibacterial activities against both gram-positive and gram-negative bacteria tested. Both derivatives of 2-aminobenzothiazole were active against the multiresistant bacteria with IZD ranging from 9 -18 mm [5] and 9 - 20mm [4]. From the MIC results it is observed that the [5] derivative produced a better antibacterial activity than the [4] derivative. The lethal concentrations (LC50) of the compounds were also determined. Their solubilities and melting points were also determined.
publisher Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP
publishDate 2011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702011000100001
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AT chahkf synthesisspectroscopiccharacterizationandantibacterialscreeningofnovelnbenzothiazol2ylethanamides
AT anagaao synthesisspectroscopiccharacterizationandantibacterialscreeningofnovelnbenzothiazol2ylethanamides
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