ESTUDO DA ATIVIDADE ANTITUMORAL DE UM NOVO COMPLEXO DE RU3+: UMA PROPOSTA PARA O DESIGN DE METALOFÁRMACOS DE BAIXA TOXICIDADE
In this article the synthesis, characterization, acute toxicity, and antitumor activity of the novel Ru3+ complex are described. Through the acute toxicity tests, it was possible to fit the complexes into categories according to the OECD protocol guideline 423. The cisplatin complex was classified in category 1 and the sodium diaquodimalonateruthenate(3+) - Na[Ru(H2O)2(Mal-κ2O)2] - was classified in category 4. This result demonstrates the lower toxicity achieved by the ruthenium complex in comparison with metallopharmaceuticals compound. Evaluations of tumor masses extracted from mice inoculated with Ehrlich ascites carcinoma demonstrated percent inhibition lowest to cisplatin. Cisplatin showed 58% inhibition (1 mg/kg), while Na[Ru(H2O)2(Mal-κ2O)2] complex (5 mg/kg) presented 77%.
Main Authors: | Andrade,Maria Helena P. S. de, Aguiar,Jaciana S., Silva,Teresinha G. da, Santos,Jandyson M., Silva,Wagner E., Belian,Mônica F. |
---|---|
Format: | Digital revista |
Language: | Portuguese |
Published: |
Sociedade Brasileira de Química
2022
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422022000800906 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
COMPLEXOS DE PLATINA(II) CONJUGADO E ANÁLOGO A O-GLICOSÍDEOS: SÍNTESE, CARACTERIZAÇÃO ESTRUTURAL E ATIVIDADE ANTITUMORAL
by: Lima,Lidiane M. A. de, et al.
Published: (2020) -
CONSIDERAÇÕES SOBRE TEXTOS QUE TRATAM DO DESENVOLVIMENTO DE METALOFÁRMACOS DE RUTÊNIO
by: Nikolaou,Sofia, et al.
Published: (2018) -
UM NOVO COMPLEXO HÍBRIDO FORMADO A PARTIR DE PIPLARTINA E O ÍON VANADILA: SÍNTESE, CARACTERIZAÇÃO E ESTUDO DA ATIVIDADE BIOLÓGICA
by: Bezerra,Giselle B., et al.
Published: (2017) -
Cytotoxic, antitumor and leukocyte migration activities of resveratrol and sitosterol present in the hidroalcoholic extract of Cissus sicyoides L., Vitaceae, leaves
by: Lucena,Flávia R. S., et al.
Published: (2010) -
Reduction Potential of RuIII-Based Complexes with Potential Antitumor Activity and Thermodynamics of their Hydrolysis Reactions and Interactions with Possible Biological Targets: a Theoretical Investigation
by: Pereira,Eufrásia S., et al.
Published: (2019)