Constituintes químicos dos galhos de Simaba guianensis subesp. ecaudata (Cronquist)
Simaba guianensis subesp. ecaudata (Simaroubaceae) is a tree found in the Brazilian Amazon. This work describes for the first time the fractionation of stems of this species that resulted in the isolation of the cytotoxic triterpene piscidinol A, the alkaloid 9-methoxycanthin-6-one, caryophyllene oxide, also isolated for the first time from this species and a new alkaloid (6-methoxy-(9H-β-carbolin-1-il)-(Z)-2-propenoic acid). Quantification of 9-methoxycanthin-6-one in different extracts and fractions of stems of S. guianensis by high performance liquid chromatography was also performed. The concentration of 9-methoxycanthin-6-one in methanolic and aqueous extracts were inferior to the known cytotoxic concentration of this compound.
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Sociedade Brasileira de Química
2012
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oai:scielo:S0100-404220120011000092012-11-30Constituintes químicos dos galhos de Simaba guianensis subesp. ecaudata (Cronquist)Nunomura,Rita de Cássia SaraivaPinto,Angelo C.Nunomura,Sergio MassayoshiPohlit,Adrian MartinAmaral,Ana Cláudia Fernandes piscidinol A 9-methoxycanthin-6-one HPLC Simaba guianensis subesp. ecaudata (Simaroubaceae) is a tree found in the Brazilian Amazon. This work describes for the first time the fractionation of stems of this species that resulted in the isolation of the cytotoxic triterpene piscidinol A, the alkaloid 9-methoxycanthin-6-one, caryophyllene oxide, also isolated for the first time from this species and a new alkaloid (6-methoxy-(9H-β-carbolin-1-il)-(Z)-2-propenoic acid). Quantification of 9-methoxycanthin-6-one in different extracts and fractions of stems of S. guianensis by high performance liquid chromatography was also performed. The concentration of 9-methoxycanthin-6-one in methanolic and aqueous extracts were inferior to the known cytotoxic concentration of this compound.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaQuímica Nova v.35 n.11 20122012-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100009pt10.1590/S0100-40422012001100009 |
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Nunomura,Rita de Cássia Saraiva Pinto,Angelo C. Nunomura,Sergio Massayoshi Pohlit,Adrian Martin Amaral,Ana Cláudia Fernandes |
| spellingShingle |
Nunomura,Rita de Cássia Saraiva Pinto,Angelo C. Nunomura,Sergio Massayoshi Pohlit,Adrian Martin Amaral,Ana Cláudia Fernandes Constituintes químicos dos galhos de Simaba guianensis subesp. ecaudata (Cronquist) |
| author_facet |
Nunomura,Rita de Cássia Saraiva Pinto,Angelo C. Nunomura,Sergio Massayoshi Pohlit,Adrian Martin Amaral,Ana Cláudia Fernandes |
| author_sort |
Nunomura,Rita de Cássia Saraiva |
| title |
Constituintes químicos dos galhos de Simaba guianensis subesp. ecaudata (Cronquist) |
| title_short |
Constituintes químicos dos galhos de Simaba guianensis subesp. ecaudata (Cronquist) |
| title_full |
Constituintes químicos dos galhos de Simaba guianensis subesp. ecaudata (Cronquist) |
| title_fullStr |
Constituintes químicos dos galhos de Simaba guianensis subesp. ecaudata (Cronquist) |
| title_full_unstemmed |
Constituintes químicos dos galhos de Simaba guianensis subesp. ecaudata (Cronquist) |
| title_sort |
constituintes químicos dos galhos de simaba guianensis subesp. ecaudata (cronquist) |
| description |
Simaba guianensis subesp. ecaudata (Simaroubaceae) is a tree found in the Brazilian Amazon. This work describes for the first time the fractionation of stems of this species that resulted in the isolation of the cytotoxic triterpene piscidinol A, the alkaloid 9-methoxycanthin-6-one, caryophyllene oxide, also isolated for the first time from this species and a new alkaloid (6-methoxy-(9H-β-carbolin-1-il)-(Z)-2-propenoic acid). Quantification of 9-methoxycanthin-6-one in different extracts and fractions of stems of S. guianensis by high performance liquid chromatography was also performed. The concentration of 9-methoxycanthin-6-one in methanolic and aqueous extracts were inferior to the known cytotoxic concentration of this compound. |
| publisher |
Sociedade Brasileira de Química |
| publishDate |
2012 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100009 |
| work_keys_str_mv |
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