Síntese e avaliação preliminar da atividade antibacteriana e antifúngica de derivados N-acilidrazônicos
We describe the synthesis and evaluation of N-acylhydrazone compounds bearing different electron-donating groups in one of its aromatic rings, obtained using a four-step synthetic route. IC50 values against pathogenic fungi and bacteria were determined by serial microdilution. Compounds showed low activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. By contrast, a derivative with a meta-oriented electron-donating group showed significant activity (IC50) against Candida albicans (17 µM), C. krusei (34 µM) and C. tropicalis (17 µM). Results suggest this is a promising lead-compound for synthesis of potent antifungal agents.
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Sociedade Brasileira de Química
2012
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000800014 |
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oai:scielo:S0100-404220120008000142012-09-05Síntese e avaliação preliminar da atividade antibacteriana e antifúngica de derivados N-acilidrazônicosCachiba,Thomas HaruoCarvalho,Bruno DemartiniCarvalho,Diogo TeixeiraCusinato,MarinaPrado,Clara GaviãoDias,Amanda Latercia Tranches N-acylhydrazones antibacterial activity antifungal activity We describe the synthesis and evaluation of N-acylhydrazone compounds bearing different electron-donating groups in one of its aromatic rings, obtained using a four-step synthetic route. IC50 values against pathogenic fungi and bacteria were determined by serial microdilution. Compounds showed low activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. By contrast, a derivative with a meta-oriented electron-donating group showed significant activity (IC50) against Candida albicans (17 µM), C. krusei (34 µM) and C. tropicalis (17 µM). Results suggest this is a promising lead-compound for synthesis of potent antifungal agents.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaQuímica Nova v.35 n.8 20122012-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000800014pt10.1590/S0100-40422012000800014 |
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Cachiba,Thomas Haruo Carvalho,Bruno Demartini Carvalho,Diogo Teixeira Cusinato,Marina Prado,Clara Gavião Dias,Amanda Latercia Tranches |
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Cachiba,Thomas Haruo Carvalho,Bruno Demartini Carvalho,Diogo Teixeira Cusinato,Marina Prado,Clara Gavião Dias,Amanda Latercia Tranches Síntese e avaliação preliminar da atividade antibacteriana e antifúngica de derivados N-acilidrazônicos |
| author_facet |
Cachiba,Thomas Haruo Carvalho,Bruno Demartini Carvalho,Diogo Teixeira Cusinato,Marina Prado,Clara Gavião Dias,Amanda Latercia Tranches |
| author_sort |
Cachiba,Thomas Haruo |
| title |
Síntese e avaliação preliminar da atividade antibacteriana e antifúngica de derivados N-acilidrazônicos |
| title_short |
Síntese e avaliação preliminar da atividade antibacteriana e antifúngica de derivados N-acilidrazônicos |
| title_full |
Síntese e avaliação preliminar da atividade antibacteriana e antifúngica de derivados N-acilidrazônicos |
| title_fullStr |
Síntese e avaliação preliminar da atividade antibacteriana e antifúngica de derivados N-acilidrazônicos |
| title_full_unstemmed |
Síntese e avaliação preliminar da atividade antibacteriana e antifúngica de derivados N-acilidrazônicos |
| title_sort |
síntese e avaliação preliminar da atividade antibacteriana e antifúngica de derivados n-acilidrazônicos |
| description |
We describe the synthesis and evaluation of N-acylhydrazone compounds bearing different electron-donating groups in one of its aromatic rings, obtained using a four-step synthetic route. IC50 values against pathogenic fungi and bacteria were determined by serial microdilution. Compounds showed low activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. By contrast, a derivative with a meta-oriented electron-donating group showed significant activity (IC50) against Candida albicans (17 µM), C. krusei (34 µM) and C. tropicalis (17 µM). Results suggest this is a promising lead-compound for synthesis of potent antifungal agents. |
| publisher |
Sociedade Brasileira de Química |
| publishDate |
2012 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000800014 |
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