Síntese e avaliação preliminar da atividade antibacteriana e antifúngica de derivados N-acilidrazônicos
We describe the synthesis and evaluation of N-acylhydrazone compounds bearing different electron-donating groups in one of its aromatic rings, obtained using a four-step synthetic route. IC50 values against pathogenic fungi and bacteria were determined by serial microdilution. Compounds showed low activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. By contrast, a derivative with a meta-oriented electron-donating group showed significant activity (IC50) against Candida albicans (17 µM), C. krusei (34 µM) and C. tropicalis (17 µM). Results suggest this is a promising lead-compound for synthesis of potent antifungal agents.
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| Main Authors: | , , , , , |
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| Format: | Digital revista |
| Language: | Portuguese |
| Published: |
Sociedade Brasileira de Química
2012
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000800014 |
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| Summary: | We describe the synthesis and evaluation of N-acylhydrazone compounds bearing different electron-donating groups in one of its aromatic rings, obtained using a four-step synthetic route. IC50 values against pathogenic fungi and bacteria were determined by serial microdilution. Compounds showed low activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. By contrast, a derivative with a meta-oriented electron-donating group showed significant activity (IC50) against Candida albicans (17 µM), C. krusei (34 µM) and C. tropicalis (17 µM). Results suggest this is a promising lead-compound for synthesis of potent antifungal agents. |
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