Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin

Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin

This laboratory project is planned for an undergraduate chemistry laboratory in which students prepare a manganese porphyrin able to mimic the oxidative metabolism of carbamazepine, one of the most frequently prescribed drugs in the treatment of epilepsy. The in vitro oxidation of carbamazepine results in the formation of the corresponding 10,11-epoxide, the main in vivo metabolite. The reaction is catalyzed by manganese porphyrin in the presence of H2O2, an environmentally-friendly oxidant. Through this project students will develop their skills in organic synthesis, coordination chemistry, chromatographic techniques such as TLC and HPLC, UV-visible spectrophotometry, and NMR spectroscopy.

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Main Authors: Neves,Cláudia M. B., Simões,Mário M. Q., Domingues,Fernando M. J., Neves,M. Graça P. M. S., Cavaleiro,José A. S.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2012
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000700033
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spelling oai:scielo:S0100-404220120007000332012-08-16Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrinNeves,Cláudia M. B.Simões,Mário M. Q.Domingues,Fernando M. J.Neves,M. Graça P. M. S.Cavaleiro,José A. S. Mn(III) porphyrin catalysis epoxidation This laboratory project is planned for an undergraduate chemistry laboratory in which students prepare a manganese porphyrin able to mimic the oxidative metabolism of carbamazepine, one of the most frequently prescribed drugs in the treatment of epilepsy. The in vitro oxidation of carbamazepine results in the formation of the corresponding 10,11-epoxide, the main in vivo metabolite. The reaction is catalyzed by manganese porphyrin in the presence of H2O2, an environmentally-friendly oxidant. Through this project students will develop their skills in organic synthesis, coordination chemistry, chromatographic techniques such as TLC and HPLC, UV-visible spectrophotometry, and NMR spectroscopy.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaQuímica Nova v.35 n.7 20122012-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000700033en10.1590/S0100-40422012000700033
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country Brasil
countrycode BR
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region America del Sur
libraryname SciELO
language English
format Digital
author Neves,Cláudia M. B.
Simões,Mário M. Q.
Domingues,Fernando M. J.
Neves,M. Graça P. M. S.
Cavaleiro,José A. S.
spellingShingle Neves,Cláudia M. B.
Simões,Mário M. Q.
Domingues,Fernando M. J.
Neves,M. Graça P. M. S.
Cavaleiro,José A. S.
Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin
author_facet Neves,Cláudia M. B.
Simões,Mário M. Q.
Domingues,Fernando M. J.
Neves,M. Graça P. M. S.
Cavaleiro,José A. S.
author_sort Neves,Cláudia M. B.
title Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin
title_short Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin
title_full Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin
title_fullStr Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin
title_full_unstemmed Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin
title_sort biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin
description This laboratory project is planned for an undergraduate chemistry laboratory in which students prepare a manganese porphyrin able to mimic the oxidative metabolism of carbamazepine, one of the most frequently prescribed drugs in the treatment of epilepsy. The in vitro oxidation of carbamazepine results in the formation of the corresponding 10,11-epoxide, the main in vivo metabolite. The reaction is catalyzed by manganese porphyrin in the presence of H2O2, an environmentally-friendly oxidant. Through this project students will develop their skills in organic synthesis, coordination chemistry, chromatographic techniques such as TLC and HPLC, UV-visible spectrophotometry, and NMR spectroscopy.
publisher Sociedade Brasileira de Química
publishDate 2012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000700033
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AT nevesmgracapms biomimeticoxidationofcarbamazepinewithhydrogenperoxidecatalyzedbyamanganeseporphyrin
AT cavaleirojoseas biomimeticoxidationofcarbamazepinewithhydrogenperoxidecatalyzedbyamanganeseporphyrin
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