Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance
A new series of 3-chloro-1-{[2-(6-nitro-1H-indazol-1-yl)ethyl]amino}-4-(substituted phenyl)-2-azetidinones (4a-j) was synthesized in four steps from 6-nitro-1H-indazole and characterized by IR, ¹H NMR, 13C NMR, FAB-mass spectrometry and chemical methods. Compounds 4(a-j) were screened in vitro for their antibacterial, antifungal and antitubercular activities against some selected microorganism and for their antiinflammatory activity (in vivo) against albino rats (either sex). All above activities of compounds 4(a-j) showed acceptable results.
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Sociedade Brasileira de Química
2012
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oai:scielo:S0100-404220120005000102012-07-02Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importanceSamadhiya,PushkalSharma,RituSrivastava,Santosh K.Srivastava,S. D. synthesis azetidinone biosignificance A new series of 3-chloro-1-{[2-(6-nitro-1H-indazol-1-yl)ethyl]amino}-4-(substituted phenyl)-2-azetidinones (4a-j) was synthesized in four steps from 6-nitro-1H-indazole and characterized by IR, ¹H NMR, 13C NMR, FAB-mass spectrometry and chemical methods. Compounds 4(a-j) were screened in vitro for their antibacterial, antifungal and antitubercular activities against some selected microorganism and for their antiinflammatory activity (in vivo) against albino rats (either sex). All above activities of compounds 4(a-j) showed acceptable results.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaQuímica Nova v.35 n.5 20122012-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000500010en10.1590/S0100-40422012000500010 |
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| author |
Samadhiya,Pushkal Sharma,Ritu Srivastava,Santosh K. Srivastava,S. D. |
| spellingShingle |
Samadhiya,Pushkal Sharma,Ritu Srivastava,Santosh K. Srivastava,S. D. Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance |
| author_facet |
Samadhiya,Pushkal Sharma,Ritu Srivastava,Santosh K. Srivastava,S. D. |
| author_sort |
Samadhiya,Pushkal |
| title |
Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance |
| title_short |
Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance |
| title_full |
Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance |
| title_fullStr |
Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance |
| title_full_unstemmed |
Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance |
| title_sort |
synthesis of 2-azetidinone derivatives of 6-nitro-1h-indazole and their biological importance |
| description |
A new series of 3-chloro-1-{[2-(6-nitro-1H-indazol-1-yl)ethyl]amino}-4-(substituted phenyl)-2-azetidinones (4a-j) was synthesized in four steps from 6-nitro-1H-indazole and characterized by IR, ¹H NMR, 13C NMR, FAB-mass spectrometry and chemical methods. Compounds 4(a-j) were screened in vitro for their antibacterial, antifungal and antitubercular activities against some selected microorganism and for their antiinflammatory activity (in vivo) against albino rats (either sex). All above activities of compounds 4(a-j) showed acceptable results. |
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Sociedade Brasileira de Química |
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2012 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000500010 |
| work_keys_str_mv |
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| _version_ |
1756387476147011584 |