In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)

Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared to benznidazole (IC50 43.14 µg/mL). Otherwise, (-)- α-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 µg/mL) while (-)-pinane showed an IC50 of 56.50 µg/mL. The obtained results indicated that the epoxydation of α-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.

Bibliographic Details

Main Authors:	Sartorelli,Patricia, Santana,Jefferson S., Guadagnin,Rafael C., Lago,João Henrique G., Pinto,Érika G., Tempone,André G., Stefani,Hélio A., Soares,Marisi G., Silva,Adalberto M. da
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2012
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400017
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