Austin, dehydroaustin and other metabolites from Penicillium brasilianum

Austin, dehydroaustin and other metabolites from Penicillium brasilianum

A culture of P. brasilianum, isolated from soil collected at the Serra do Cipó National Park, in Minas Gerais State (Brazil), was grown for 25 days on a dextrose-peptone-salts medium. The corresponding ethylacetate extract was column chromatographed and four compounds were isolated: austin, dehydroaustin, D-mannitol and penicillic acid. This is, in the best of our knowledge, the first time that the meroterpenes austin and dehydroaustin have been isolated from this species. Activity of the extract and isolated compounds was tested against six bacteria and for acetylcholinesterase inhibition. Penicillic acid showed high activity in both tests.

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Main Authors: Schürmann,Betânia T. M., Sallum,William S. T., Takahashi,Jacqueline A.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2010
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000500007
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spelling oai:scielo:S0100-404220100005000072010-07-23Austin, dehydroaustin and other metabolites from Penicillium brasilianumSchürmann,Betânia T. M.Sallum,William S. T.Takahashi,Jacqueline A. Austin dehydroaustin Penicillium brasilianum A culture of P. brasilianum, isolated from soil collected at the Serra do Cipó National Park, in Minas Gerais State (Brazil), was grown for 25 days on a dextrose-peptone-salts medium. The corresponding ethylacetate extract was column chromatographed and four compounds were isolated: austin, dehydroaustin, D-mannitol and penicillic acid. This is, in the best of our knowledge, the first time that the meroterpenes austin and dehydroaustin have been isolated from this species. Activity of the extract and isolated compounds was tested against six bacteria and for acetylcholinesterase inhibition. Penicillic acid showed high activity in both tests.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaQuímica Nova v.33 n.5 20102010-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000500007en10.1590/S0100-40422010000500007
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Schürmann,Betânia T. M.
Sallum,William S. T.
Takahashi,Jacqueline A.
spellingShingle Schürmann,Betânia T. M.
Sallum,William S. T.
Takahashi,Jacqueline A.
Austin, dehydroaustin and other metabolites from Penicillium brasilianum
author_facet Schürmann,Betânia T. M.
Sallum,William S. T.
Takahashi,Jacqueline A.
author_sort Schürmann,Betânia T. M.
title Austin, dehydroaustin and other metabolites from Penicillium brasilianum
title_short Austin, dehydroaustin and other metabolites from Penicillium brasilianum
title_full Austin, dehydroaustin and other metabolites from Penicillium brasilianum
title_fullStr Austin, dehydroaustin and other metabolites from Penicillium brasilianum
title_full_unstemmed Austin, dehydroaustin and other metabolites from Penicillium brasilianum
title_sort austin, dehydroaustin and other metabolites from penicillium brasilianum
description A culture of P. brasilianum, isolated from soil collected at the Serra do Cipó National Park, in Minas Gerais State (Brazil), was grown for 25 days on a dextrose-peptone-salts medium. The corresponding ethylacetate extract was column chromatographed and four compounds were isolated: austin, dehydroaustin, D-mannitol and penicillic acid. This is, in the best of our knowledge, the first time that the meroterpenes austin and dehydroaustin have been isolated from this species. Activity of the extract and isolated compounds was tested against six bacteria and for acetylcholinesterase inhibition. Penicillic acid showed high activity in both tests.
publisher Sociedade Brasileira de Química
publishDate 2010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000500007
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AT sallumwilliamst austindehydroaustinandothermetabolitesfrompenicilliumbrasilianum
AT takahashijacquelinea austindehydroaustinandothermetabolitesfrompenicilliumbrasilianum
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