Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets

Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets

This work aimed the development and validation of a new dissolution test for ornidazole coated tablets. The dissolution conditions were determined after testing Sink conditions, dissolution medium, apparatus, stirring speed, 24 h stability and medium filtration influence. The best conditions were paddle at a stirring speed of 75 rpm and 900 mL of 0.1 M HCl. A new HPLC quantification method was developed and validated. The dissolution test and quantification method showed to be adequate for their purposes and could be applied for quality control of ornidazole coated tablets, since there is no official monograph.

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Main Authors: Soares,Mônica Felts de La Roca, Soares Sobrinho,José Lamartine, Grangeiro Júnior,Severino, Silva,Keyla Emanuelle Ramos da, Alves,Lariza Darlene Santos, Rolim Neto,Pedro José
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2010
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200042
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spelling oai:scielo:S0100-404220100002000422010-03-12Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tabletsSoares,Mônica Felts de La RocaSoares Sobrinho,José LamartineGrangeiro Júnior,SeverinoSilva,Keyla Emanuelle Ramos daAlves,Lariza Darlene SantosRolim Neto,Pedro José ornidazole quality control dissolution test This work aimed the development and validation of a new dissolution test for ornidazole coated tablets. The dissolution conditions were determined after testing Sink conditions, dissolution medium, apparatus, stirring speed, 24 h stability and medium filtration influence. The best conditions were paddle at a stirring speed of 75 rpm and 900 mL of 0.1 M HCl. A new HPLC quantification method was developed and validated. The dissolution test and quantification method showed to be adequate for their purposes and could be applied for quality control of ornidazole coated tablets, since there is no official monograph.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaQuímica Nova v.33 n.2 20102010-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200042en10.1590/S0100-40422010000200042
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Soares,Mônica Felts de La Roca
Soares Sobrinho,José Lamartine
Grangeiro Júnior,Severino
Silva,Keyla Emanuelle Ramos da
Alves,Lariza Darlene Santos
Rolim Neto,Pedro José
spellingShingle Soares,Mônica Felts de La Roca
Soares Sobrinho,José Lamartine
Grangeiro Júnior,Severino
Silva,Keyla Emanuelle Ramos da
Alves,Lariza Darlene Santos
Rolim Neto,Pedro José
Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
author_facet Soares,Mônica Felts de La Roca
Soares Sobrinho,José Lamartine
Grangeiro Júnior,Severino
Silva,Keyla Emanuelle Ramos da
Alves,Lariza Darlene Santos
Rolim Neto,Pedro José
author_sort Soares,Mônica Felts de La Roca
title Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
title_short Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
title_full Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
title_fullStr Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
title_full_unstemmed Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
title_sort development of new dissolution test and hplc-rp method for anti-parasitic ornidazole coated tablets
description This work aimed the development and validation of a new dissolution test for ornidazole coated tablets. The dissolution conditions were determined after testing Sink conditions, dissolution medium, apparatus, stirring speed, 24 h stability and medium filtration influence. The best conditions were paddle at a stirring speed of 75 rpm and 900 mL of 0.1 M HCl. A new HPLC quantification method was developed and validated. The dissolution test and quantification method showed to be adequate for their purposes and could be applied for quality control of ornidazole coated tablets, since there is no official monograph.
publisher Sociedade Brasileira de Química
publishDate 2010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200042
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AT soaressobrinhojoselamartine developmentofnewdissolutiontestandhplcrpmethodforantiparasiticornidazolecoatedtablets
AT grangeirojuniorseverino developmentofnewdissolutiontestandhplcrpmethodforantiparasiticornidazolecoatedtablets
AT silvakeylaemanuelleramosda developmentofnewdissolutiontestandhplcrpmethodforantiparasiticornidazolecoatedtablets
AT alveslarizadarlenesantos developmentofnewdissolutiontestandhplcrpmethodforantiparasiticornidazolecoatedtablets
AT rolimnetopedrojose developmentofnewdissolutiontestandhplcrpmethodforantiparasiticornidazolecoatedtablets
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