Losartan potassium dissolution test for drug release evaluation in pharmaceutical capsules using HPLC and UV spectrophotometry

Losartan potassium dissolution test for drug release evaluation in pharmaceutical capsules using HPLC and UV spectrophotometry

This work describes the development and validation of a dissolution test for 50 mg losartan potassium capsules using HPLC and UV spectrophotometry. A 2(4) full factorial design was carried out to optimize dissolution conditions and potassium phosphate buffer, pH 6.8 as dissolution medium, basket as apparatus at the stirring speed of 50 rpm and time of 30 min were considered adequate. Both dissolution procedure and analytical methods were validated and a statistical analysis showed that there are no significant differences between HPLC and spectrophotometry. Since there is no official monograph, this dissolution test could be applied for quality control routine.

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Main Authors: Bonfilio,Rudy, Mendonça,Taciane Ferreira, Pereira,Gislaine Ribeiro, Araújo,Magali Benjamim de, Tarley,César Ricardo Teixeira
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2010
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200026
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spelling oai:scielo:S0100-404220100002000262010-03-12Losartan potassium dissolution test for drug release evaluation in pharmaceutical capsules using HPLC and UV spectrophotometryBonfilio,RudyMendonça,Taciane FerreiraPereira,Gislaine RibeiroAraújo,Magali Benjamim deTarley,César Ricardo Teixeira losartan potassium full factorial design dissolution This work describes the development and validation of a dissolution test for 50 mg losartan potassium capsules using HPLC and UV spectrophotometry. A 2(4) full factorial design was carried out to optimize dissolution conditions and potassium phosphate buffer, pH 6.8 as dissolution medium, basket as apparatus at the stirring speed of 50 rpm and time of 30 min were considered adequate. Both dissolution procedure and analytical methods were validated and a statistical analysis showed that there are no significant differences between HPLC and spectrophotometry. Since there is no official monograph, this dissolution test could be applied for quality control routine.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaQuímica Nova v.33 n.2 20102010-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200026en10.1590/S0100-40422010000200026
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Bonfilio,Rudy
Mendonça,Taciane Ferreira
Pereira,Gislaine Ribeiro
Araújo,Magali Benjamim de
Tarley,César Ricardo Teixeira
spellingShingle Bonfilio,Rudy
Mendonça,Taciane Ferreira
Pereira,Gislaine Ribeiro
Araújo,Magali Benjamim de
Tarley,César Ricardo Teixeira
Losartan potassium dissolution test for drug release evaluation in pharmaceutical capsules using HPLC and UV spectrophotometry
author_facet Bonfilio,Rudy
Mendonça,Taciane Ferreira
Pereira,Gislaine Ribeiro
Araújo,Magali Benjamim de
Tarley,César Ricardo Teixeira
author_sort Bonfilio,Rudy
title Losartan potassium dissolution test for drug release evaluation in pharmaceutical capsules using HPLC and UV spectrophotometry
title_short Losartan potassium dissolution test for drug release evaluation in pharmaceutical capsules using HPLC and UV spectrophotometry
title_full Losartan potassium dissolution test for drug release evaluation in pharmaceutical capsules using HPLC and UV spectrophotometry
title_fullStr Losartan potassium dissolution test for drug release evaluation in pharmaceutical capsules using HPLC and UV spectrophotometry
title_full_unstemmed Losartan potassium dissolution test for drug release evaluation in pharmaceutical capsules using HPLC and UV spectrophotometry
title_sort losartan potassium dissolution test for drug release evaluation in pharmaceutical capsules using hplc and uv spectrophotometry
description This work describes the development and validation of a dissolution test for 50 mg losartan potassium capsules using HPLC and UV spectrophotometry. A 2(4) full factorial design was carried out to optimize dissolution conditions and potassium phosphate buffer, pH 6.8 as dissolution medium, basket as apparatus at the stirring speed of 50 rpm and time of 30 min were considered adequate. Both dissolution procedure and analytical methods were validated and a statistical analysis showed that there are no significant differences between HPLC and spectrophotometry. Since there is no official monograph, this dissolution test could be applied for quality control routine.
publisher Sociedade Brasileira de Química
publishDate 2010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200026
work_keys_str_mv AT bonfiliorudy losartanpotassiumdissolutiontestfordrugreleaseevaluationinpharmaceuticalcapsulesusinghplcanduvspectrophotometry
AT mendoncatacianeferreira losartanpotassiumdissolutiontestfordrugreleaseevaluationinpharmaceuticalcapsulesusinghplcanduvspectrophotometry
AT pereiragislaineribeiro losartanpotassiumdissolutiontestfordrugreleaseevaluationinpharmaceuticalcapsulesusinghplcanduvspectrophotometry
AT araujomagalibenjamimde losartanpotassiumdissolutiontestfordrugreleaseevaluationinpharmaceuticalcapsulesusinghplcanduvspectrophotometry
AT tarleycesarricardoteixeira losartanpotassiumdissolutiontestfordrugreleaseevaluationinpharmaceuticalcapsulesusinghplcanduvspectrophotometry
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