Microextração em fase líquida (LPME): fundamentos da técnica e aplicações na análise de fármacos em fluidos biológicos

Microextração em fase líquida (LPME): fundamentos da técnica e aplicações na análise de fármacos em fluidos biológicos

The analysis of drugs and metabolites in biological fluids usually requires extraction procedures to achieve sample clean-up and analyte preconcentration. Commonly, extraction procedures are performed using liquid-liquid extraction or solid-phase extraction. Nevertheless, these extraction techniques are considered to be time-consuming and require a large amount of organic solvents. On this basis, microextraction techniques have been developed. Among them, liquid-phase microextraction has been standing out. This review describes the liquid-phase microextraction technique based on hollow fibers as a novel and promising alternative in sample preparation prior to chromatographic or electrophoretic analysis. The basic concepts related to this technique and its applicability in extraction of drugs are discussed.

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Main Authors: Oliveira,Anderson Rodrigo Moraes de, Magalhães,Igor Rafael dos Santos, Santana,Fernando José Malagueño de, Bonato,Pierina Sueli
Format: Digital revista
Language:Portuguese
Published: Sociedade Brasileira de Química 2008
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000300031
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spelling oai:scielo:S0100-404220080003000312008-06-13Microextração em fase líquida (LPME): fundamentos da técnica e aplicações na análise de fármacos em fluidos biológicosOliveira,Anderson Rodrigo Moraes deMagalhães,Igor Rafael dos SantosSantana,Fernando José Malagueño deBonato,Pierina Sueli liquid-phase microextraction drug analysis biological samples The analysis of drugs and metabolites in biological fluids usually requires extraction procedures to achieve sample clean-up and analyte preconcentration. Commonly, extraction procedures are performed using liquid-liquid extraction or solid-phase extraction. Nevertheless, these extraction techniques are considered to be time-consuming and require a large amount of organic solvents. On this basis, microextraction techniques have been developed. Among them, liquid-phase microextraction has been standing out. This review describes the liquid-phase microextraction technique based on hollow fibers as a novel and promising alternative in sample preparation prior to chromatographic or electrophoretic analysis. The basic concepts related to this technique and its applicability in extraction of drugs are discussed.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaQuímica Nova v.31 n.3 20082008-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000300031pt10.1590/S0100-40422008000300031
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country Brasil
countrycode BR
component Revista
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databasecode rev-scielo-br
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region America del Sur
libraryname SciELO
language Portuguese
format Digital
author Oliveira,Anderson Rodrigo Moraes de
Magalhães,Igor Rafael dos Santos
Santana,Fernando José Malagueño de
Bonato,Pierina Sueli
spellingShingle Oliveira,Anderson Rodrigo Moraes de
Magalhães,Igor Rafael dos Santos
Santana,Fernando José Malagueño de
Bonato,Pierina Sueli
Microextração em fase líquida (LPME): fundamentos da técnica e aplicações na análise de fármacos em fluidos biológicos
author_facet Oliveira,Anderson Rodrigo Moraes de
Magalhães,Igor Rafael dos Santos
Santana,Fernando José Malagueño de
Bonato,Pierina Sueli
author_sort Oliveira,Anderson Rodrigo Moraes de
title Microextração em fase líquida (LPME): fundamentos da técnica e aplicações na análise de fármacos em fluidos biológicos
title_short Microextração em fase líquida (LPME): fundamentos da técnica e aplicações na análise de fármacos em fluidos biológicos
title_full Microextração em fase líquida (LPME): fundamentos da técnica e aplicações na análise de fármacos em fluidos biológicos
title_fullStr Microextração em fase líquida (LPME): fundamentos da técnica e aplicações na análise de fármacos em fluidos biológicos
title_full_unstemmed Microextração em fase líquida (LPME): fundamentos da técnica e aplicações na análise de fármacos em fluidos biológicos
title_sort microextração em fase líquida (lpme): fundamentos da técnica e aplicações na análise de fármacos em fluidos biológicos
description The analysis of drugs and metabolites in biological fluids usually requires extraction procedures to achieve sample clean-up and analyte preconcentration. Commonly, extraction procedures are performed using liquid-liquid extraction or solid-phase extraction. Nevertheless, these extraction techniques are considered to be time-consuming and require a large amount of organic solvents. On this basis, microextraction techniques have been developed. Among them, liquid-phase microextraction has been standing out. This review describes the liquid-phase microextraction technique based on hollow fibers as a novel and promising alternative in sample preparation prior to chromatographic or electrophoretic analysis. The basic concepts related to this technique and its applicability in extraction of drugs are discussed.
publisher Sociedade Brasileira de Química
publishDate 2008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000300031
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AT magalhaesigorrafaeldossantos microextracaoemfaseliquidalpmefundamentosdatecnicaeaplicacoesnaanalisedefarmacosemfluidosbiologicos
AT santanafernandojosemalaguenode microextracaoemfaseliquidalpmefundamentosdatecnicaeaplicacoesnaanalisedefarmacosemfluidosbiologicos
AT bonatopierinasueli microextracaoemfaseliquidalpmefundamentosdatecnicaeaplicacoesnaanalisedefarmacosemfluidosbiologicos
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