Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules
Zidovudine (AZT) and stavudine (D4T) are nucleoside reverse transcriptase inhibitors extensively used in human immunodeficiency virus (HIV) infected patients. In order to evaluate the quality of these drugs, two stability indicating HPLC methods were developed. The validated methods were applied in quantitative determination of AZT, D4T and their induced degradation products in capsule preparations. The stability studies were conducted at controlled temperature and relative humidity conditions based on the International Conference on Harmonization stability studies protocol for Zone IV areas. Easy sample preparation and low-cost make these methods especially useful for quality control and stability studies of AZT and D4T in drug products.
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Sociedade Brasileira de Química
2006
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oai:scielo:S0100-404220060002000122006-04-03Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsulesSantoro,Maria Inês R. M.Taborianski,Andréia M.Singh,Anil KumarKedor-Hackmann,Erika R. M. liquid chromatography antiviral drugs stability studies Zidovudine (AZT) and stavudine (D4T) are nucleoside reverse transcriptase inhibitors extensively used in human immunodeficiency virus (HIV) infected patients. In order to evaluate the quality of these drugs, two stability indicating HPLC methods were developed. The validated methods were applied in quantitative determination of AZT, D4T and their induced degradation products in capsule preparations. The stability studies were conducted at controlled temperature and relative humidity conditions based on the International Conference on Harmonization stability studies protocol for Zone IV areas. Easy sample preparation and low-cost make these methods especially useful for quality control and stability studies of AZT and D4T in drug products.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaQuímica Nova v.29 n.2 20062006-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000200012en10.1590/S0100-40422006000200012 |
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Santoro,Maria Inês R. M. Taborianski,Andréia M. Singh,Anil Kumar Kedor-Hackmann,Erika R. M. |
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Santoro,Maria Inês R. M. Taborianski,Andréia M. Singh,Anil Kumar Kedor-Hackmann,Erika R. M. Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules |
author_facet |
Santoro,Maria Inês R. M. Taborianski,Andréia M. Singh,Anil Kumar Kedor-Hackmann,Erika R. M. |
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Santoro,Maria Inês R. M. |
title |
Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules |
title_short |
Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules |
title_full |
Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules |
title_fullStr |
Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules |
title_full_unstemmed |
Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules |
title_sort |
stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules |
description |
Zidovudine (AZT) and stavudine (D4T) are nucleoside reverse transcriptase inhibitors extensively used in human immunodeficiency virus (HIV) infected patients. In order to evaluate the quality of these drugs, two stability indicating HPLC methods were developed. The validated methods were applied in quantitative determination of AZT, D4T and their induced degradation products in capsule preparations. The stability studies were conducted at controlled temperature and relative humidity conditions based on the International Conference on Harmonization stability studies protocol for Zone IV areas. Easy sample preparation and low-cost make these methods especially useful for quality control and stability studies of AZT and D4T in drug products. |
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Sociedade Brasileira de Química |
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2006 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000200012 |
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