Drogas anti-VIH: passado, presente e perspectivas futuras

Drogas anti-VIH: passado, presente e perspectivas futuras

Currently available anti-HIV drugs can be classified into three categories: nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs). In addition to the reverse transcriptase (RT) and protease reaction, various other events in the HIV replicative cycle can be considered as potential targets for chemotherapeutic intervention: (1) viral adsorption, through binding to the viral envelope glycoprotein gp120; (2) viral entry, through blockage of the viral coreceptors CXCR4 and CCR5; (3) virus-cell fusion, through binding to the viral envelope glycoprotein gp 41; (4) viral assembly and disassembly through NCp7 zinc finger-targeted agents; (5) proviral DNA integration, through integrase inhibitors and (6) viral mRNA transcription, through inhibitors of the transcription (transactivation) process. Also, various new NRTIs, NNRTIs and PIs have been developed, possessing different improved characteristics.

Saved in:
Bibliographic Details
Main Authors: Souza,Marcus Vinícius Nora de, Almeida,Mauro Vieira de
Format: Digital revista
Language:Portuguese
Published: Sociedade Brasileira de Química 2003
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000300014
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:scielo:S0100-40422003000300014
record_format ojs
spelling oai:scielo:S0100-404220030003000142003-05-28Drogas anti-VIH: passado, presente e perspectivas futurasSouza,Marcus Vinícius Nora deAlmeida,Mauro Vieira de AIDS new Anti-HIV drugs replicative cycle Currently available anti-HIV drugs can be classified into three categories: nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs). In addition to the reverse transcriptase (RT) and protease reaction, various other events in the HIV replicative cycle can be considered as potential targets for chemotherapeutic intervention: (1) viral adsorption, through binding to the viral envelope glycoprotein gp120; (2) viral entry, through blockage of the viral coreceptors CXCR4 and CCR5; (3) virus-cell fusion, through binding to the viral envelope glycoprotein gp 41; (4) viral assembly and disassembly through NCp7 zinc finger-targeted agents; (5) proviral DNA integration, through integrase inhibitors and (6) viral mRNA transcription, through inhibitors of the transcription (transactivation) process. Also, various new NRTIs, NNRTIs and PIs have been developed, possessing different improved characteristics.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaQuímica Nova v.26 n.3 20032003-05-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000300014pt10.1590/S0100-40422003000300014
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language Portuguese
format Digital
author Souza,Marcus Vinícius Nora de
Almeida,Mauro Vieira de
spellingShingle Souza,Marcus Vinícius Nora de
Almeida,Mauro Vieira de
Drogas anti-VIH: passado, presente e perspectivas futuras
author_facet Souza,Marcus Vinícius Nora de
Almeida,Mauro Vieira de
author_sort Souza,Marcus Vinícius Nora de
title Drogas anti-VIH: passado, presente e perspectivas futuras
title_short Drogas anti-VIH: passado, presente e perspectivas futuras
title_full Drogas anti-VIH: passado, presente e perspectivas futuras
title_fullStr Drogas anti-VIH: passado, presente e perspectivas futuras
title_full_unstemmed Drogas anti-VIH: passado, presente e perspectivas futuras
title_sort drogas anti-vih: passado, presente e perspectivas futuras
description Currently available anti-HIV drugs can be classified into three categories: nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs). In addition to the reverse transcriptase (RT) and protease reaction, various other events in the HIV replicative cycle can be considered as potential targets for chemotherapeutic intervention: (1) viral adsorption, through binding to the viral envelope glycoprotein gp120; (2) viral entry, through blockage of the viral coreceptors CXCR4 and CCR5; (3) virus-cell fusion, through binding to the viral envelope glycoprotein gp 41; (4) viral assembly and disassembly through NCp7 zinc finger-targeted agents; (5) proviral DNA integration, through integrase inhibitors and (6) viral mRNA transcription, through inhibitors of the transcription (transactivation) process. Also, various new NRTIs, NNRTIs and PIs have been developed, possessing different improved characteristics.
publisher Sociedade Brasileira de Química
publishDate 2003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000300014
work_keys_str_mv AT souzamarcusviniciusnorade drogasantivihpassadopresenteeperspectivasfuturas
AT almeidamaurovieirade drogasantivihpassadopresenteeperspectivasfuturas
_version_ 1756387093782724608

Similar Items