Quantitative evaluation of brain volume among elderly individuals in São Paulo, Brazil: a population-based study

Abstract Objective: To perform a quantitative analysis of the brain volume of elderly individuals in a population-based sample. Materials and Methods: This was a radiological assessment and voxel-based quantitative analysis, with surface alignment, of 525 magnetic resonance imaging scans of individuals between 60 and 103 years of age who participated in the Saúde, Bem-estar e Envelhecimento (Health, Well-being, and Aging) study in the city of São Paulo, Brazil. Results: We noted a median rate of reduction in total brain volume of 2.4% per decade after 60 years of age. Gray and white matter both showed volume reductions with age. The total brain volume/intracranial brain volume ratio differed between males and females. Conclusion: We have corroborated the findings of studies conducted in the United States and Europe. The total brain volume/intracranial brain volume ratio is higher in men, representing a potential bias for the conventional radiological assessment of atrophy, which is typically based on the evaluation of the cerebrospinal fluid spaces.

Bibliographic Details

Main Authors:	Rodrigues,Mariana Athaniel Silva, Rodrigues,Thiago Pereira, Zatz,Mayana, Lebrão,Maria Lúcia, Duarte,Yeda Aparecida, Naslavsky,Michel Satya, Nascimento,Felipe Barjud Pereira do, Amaro Junior,Edson
Format:	Digital revista
Language:	English
Published:	Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem 2019
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842019000500293
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