Balloon-based adjuvant radiotherapy in breast cancer: comparison between 99mTc and HDR 192Ir

Balloon-based adjuvant radiotherapy in breast cancer: comparison between 99mTc and HDR 192Ir

Abstract Objective: To perform a comparative dosimetric analysis, based on computer simulations, of temporary balloon implants with 99mTc and balloon brachytherapy with high-dose-rate (HDR) 192Ir, as boosts to radiotherapy. We hypothesized that the two techniques would produce equivalent doses under pre-established conditions of activity and exposure time. Materials and Methods: Simulations of implants with 99mTc-filled and HDR 192Ir-filled balloons were performed with the Siscodes/MCNP5, modeling in voxels a magnetic resonance imaging set related to a young female. Spatial dose rate distributions were determined. In the dosimetric analysis of the protocols, the exposure time and the level of activity required were specified. Results: The 99mTc balloon presented a weighted dose rate in the tumor bed of 0.428 cGy.h-1.mCi-1 and 0.190 cGyh-1.mCi-1 at the balloon surface and at 8-10 mm from the surface, respectively, compared with 0.499 and 0.150 cGyh-1.mCi-1, respectively, for the HDR 192Ir balloon. An exposure time of 24 hours was required for the 99mTc balloon to produce a boost of 10.14 Gy with 1.0 Ci, whereas only 24 minutes with 10.0 Ci segments were required for the HDR 192Ir balloon to produce a boost of 5.14 Gy at the same reference point, or 10.28 Gy in two 24-minutes fractions. Conclusion: Temporary 99mTc balloon implantation is an attractive option for adjuvant radiotherapy in breast cancer, because of its availability, economic viability, and similar dosimetry in comparison with the use of HDR 192Ir balloon implantation, which is the current standard in clinical practice.

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Main Authors: Campos,Tarcísio Passos Ribeiro de, Lima,Carla Flavia de, Cuperschmid,Ethel Mizrahy
Format: Digital revista
Language:English
Published: Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem 2016
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842016000200009
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spelling oai:scielo:S0100-398420160002000092016-05-03Balloon-based adjuvant radiotherapy in breast cancer: comparison between 99mTc and HDR 192IrCampos,Tarcísio Passos Ribeiro deLima,Carla Flavia deCuperschmid,Ethel Mizrahy Breast brachytherapy Balloon Radiotherapy dosage Radiotherapy, adjuvant 99mTc 192Ir Monte Carlo method Abstract Objective: To perform a comparative dosimetric analysis, based on computer simulations, of temporary balloon implants with 99mTc and balloon brachytherapy with high-dose-rate (HDR) 192Ir, as boosts to radiotherapy. We hypothesized that the two techniques would produce equivalent doses under pre-established conditions of activity and exposure time. Materials and Methods: Simulations of implants with 99mTc-filled and HDR 192Ir-filled balloons were performed with the Siscodes/MCNP5, modeling in voxels a magnetic resonance imaging set related to a young female. Spatial dose rate distributions were determined. In the dosimetric analysis of the protocols, the exposure time and the level of activity required were specified. Results: The 99mTc balloon presented a weighted dose rate in the tumor bed of 0.428 cGy.h-1.mCi-1 and 0.190 cGyh-1.mCi-1 at the balloon surface and at 8-10 mm from the surface, respectively, compared with 0.499 and 0.150 cGyh-1.mCi-1, respectively, for the HDR 192Ir balloon. An exposure time of 24 hours was required for the 99mTc balloon to produce a boost of 10.14 Gy with 1.0 Ci, whereas only 24 minutes with 10.0 Ci segments were required for the HDR 192Ir balloon to produce a boost of 5.14 Gy at the same reference point, or 10.28 Gy in two 24-minutes fractions. Conclusion: Temporary 99mTc balloon implantation is an attractive option for adjuvant radiotherapy in breast cancer, because of its availability, economic viability, and similar dosimetry in comparison with the use of HDR 192Ir balloon implantation, which is the current standard in clinical practice.info:eu-repo/semantics/openAccessPublicação do Colégio Brasileiro de Radiologia e Diagnóstico por ImagemRadiologia Brasileira v.49 n.2 20162016-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842016000200009en10.1590/0100-3984.2015.0010
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country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
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region America del Sur
libraryname SciELO
language English
format Digital
author Campos,Tarcísio Passos Ribeiro de
Lima,Carla Flavia de
Cuperschmid,Ethel Mizrahy
spellingShingle Campos,Tarcísio Passos Ribeiro de
Lima,Carla Flavia de
Cuperschmid,Ethel Mizrahy
Balloon-based adjuvant radiotherapy in breast cancer: comparison between 99mTc and HDR 192Ir
author_facet Campos,Tarcísio Passos Ribeiro de
Lima,Carla Flavia de
Cuperschmid,Ethel Mizrahy
author_sort Campos,Tarcísio Passos Ribeiro de
title Balloon-based adjuvant radiotherapy in breast cancer: comparison between 99mTc and HDR 192Ir
title_short Balloon-based adjuvant radiotherapy in breast cancer: comparison between 99mTc and HDR 192Ir
title_full Balloon-based adjuvant radiotherapy in breast cancer: comparison between 99mTc and HDR 192Ir
title_fullStr Balloon-based adjuvant radiotherapy in breast cancer: comparison between 99mTc and HDR 192Ir
title_full_unstemmed Balloon-based adjuvant radiotherapy in breast cancer: comparison between 99mTc and HDR 192Ir
title_sort balloon-based adjuvant radiotherapy in breast cancer: comparison between 99mtc and hdr 192ir
description Abstract Objective: To perform a comparative dosimetric analysis, based on computer simulations, of temporary balloon implants with 99mTc and balloon brachytherapy with high-dose-rate (HDR) 192Ir, as boosts to radiotherapy. We hypothesized that the two techniques would produce equivalent doses under pre-established conditions of activity and exposure time. Materials and Methods: Simulations of implants with 99mTc-filled and HDR 192Ir-filled balloons were performed with the Siscodes/MCNP5, modeling in voxels a magnetic resonance imaging set related to a young female. Spatial dose rate distributions were determined. In the dosimetric analysis of the protocols, the exposure time and the level of activity required were specified. Results: The 99mTc balloon presented a weighted dose rate in the tumor bed of 0.428 cGy.h-1.mCi-1 and 0.190 cGyh-1.mCi-1 at the balloon surface and at 8-10 mm from the surface, respectively, compared with 0.499 and 0.150 cGyh-1.mCi-1, respectively, for the HDR 192Ir balloon. An exposure time of 24 hours was required for the 99mTc balloon to produce a boost of 10.14 Gy with 1.0 Ci, whereas only 24 minutes with 10.0 Ci segments were required for the HDR 192Ir balloon to produce a boost of 5.14 Gy at the same reference point, or 10.28 Gy in two 24-minutes fractions. Conclusion: Temporary 99mTc balloon implantation is an attractive option for adjuvant radiotherapy in breast cancer, because of its availability, economic viability, and similar dosimetry in comparison with the use of HDR 192Ir balloon implantation, which is the current standard in clinical practice.
publisher Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
publishDate 2016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842016000200009
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AT limacarlaflaviade balloonbasedadjuvantradiotherapyinbreastcancercomparisonbetween99mtcandhdr192ir
AT cuperschmidethelmizrahy balloonbasedadjuvantradiotherapyinbreastcancercomparisonbetween99mtcandhdr192ir
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