Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: mitochondrion as a strategic target
Over the past years, natural products have been explored in order to find biological active substances to treat various diseases. Regarding their potential action against parasites such as trypanosomatids, specially Trypanosoma cruzi and Leishmania spp., much advance has been achieved. Extracts and purified molecules of several species from genera Piper, Tanacetum, Porophyllum, and Copaifera have been widely investigated by our research group and exhibited interesting antitrypanosomal and antileishmanial activities. These natural compounds affected different structures in parasites, and we believe that the mitochondrion is a strategic target to induce parasite death. Considering that these trypanosomatids have a unique mitochondrion, this cellular target has been extensively studied aiming to find more selective drugs, since the current treatment of these neglected tropical diseases has some challenges such as high toxicity and prolonged treatment time. Here, we summarise some results obtained with natural products from our research group and we further highlighted some strategies that must be considered to finally develop an effective chemotherapeutic agent against these parasites.
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Instituto Oswaldo Cruz, Ministério da Saúde
2022
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oai:scielo:S0074-027620220001008612022-03-28Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: mitochondrion as a strategic targetLazarin-Bidóia,DanielleGarcia,Francielle PelegrinUeda-Nakamura,TâniaSilva,Sueli de OliveiraNakamura,Celso Vataru trypanosomatids natural products mitochondrion new therapeutic alternatives Over the past years, natural products have been explored in order to find biological active substances to treat various diseases. Regarding their potential action against parasites such as trypanosomatids, specially Trypanosoma cruzi and Leishmania spp., much advance has been achieved. Extracts and purified molecules of several species from genera Piper, Tanacetum, Porophyllum, and Copaifera have been widely investigated by our research group and exhibited interesting antitrypanosomal and antileishmanial activities. These natural compounds affected different structures in parasites, and we believe that the mitochondrion is a strategic target to induce parasite death. Considering that these trypanosomatids have a unique mitochondrion, this cellular target has been extensively studied aiming to find more selective drugs, since the current treatment of these neglected tropical diseases has some challenges such as high toxicity and prolonged treatment time. Here, we summarise some results obtained with natural products from our research group and we further highlighted some strategies that must be considered to finally develop an effective chemotherapeutic agent against these parasites.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.117 20222022-01-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762022000100861en10.1590/0074-02760220396 |
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Lazarin-Bidóia,Danielle Garcia,Francielle Pelegrin Ueda-Nakamura,Tânia Silva,Sueli de Oliveira Nakamura,Celso Vataru |
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Lazarin-Bidóia,Danielle Garcia,Francielle Pelegrin Ueda-Nakamura,Tânia Silva,Sueli de Oliveira Nakamura,Celso Vataru Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: mitochondrion as a strategic target |
author_facet |
Lazarin-Bidóia,Danielle Garcia,Francielle Pelegrin Ueda-Nakamura,Tânia Silva,Sueli de Oliveira Nakamura,Celso Vataru |
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Lazarin-Bidóia,Danielle |
title |
Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: mitochondrion as a strategic target |
title_short |
Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: mitochondrion as a strategic target |
title_full |
Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: mitochondrion as a strategic target |
title_fullStr |
Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: mitochondrion as a strategic target |
title_full_unstemmed |
Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: mitochondrion as a strategic target |
title_sort |
natural compounds based chemotherapeutic against chagas disease and leishmaniasis: mitochondrion as a strategic target |
description |
Over the past years, natural products have been explored in order to find biological active substances to treat various diseases. Regarding their potential action against parasites such as trypanosomatids, specially Trypanosoma cruzi and Leishmania spp., much advance has been achieved. Extracts and purified molecules of several species from genera Piper, Tanacetum, Porophyllum, and Copaifera have been widely investigated by our research group and exhibited interesting antitrypanosomal and antileishmanial activities. These natural compounds affected different structures in parasites, and we believe that the mitochondrion is a strategic target to induce parasite death. Considering that these trypanosomatids have a unique mitochondrion, this cellular target has been extensively studied aiming to find more selective drugs, since the current treatment of these neglected tropical diseases has some challenges such as high toxicity and prolonged treatment time. Here, we summarise some results obtained with natural products from our research group and we further highlighted some strategies that must be considered to finally develop an effective chemotherapeutic agent against these parasites. |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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2022 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762022000100861 |
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