The adaptation of SARS-CoV-2 to humans
The process of adaptation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to humans probably had started decades ago, when its ancestor diverged from the bat coronavirus. The adaptive process comprises strategies the virus uses to overcome the respiratory tract defense barriers and replicate and shed in the host cells. These strategies include the impairment of interferon production, hiding immunogenic motifs, avoiding viral RNA detection, manipulating cell autophagy, triggering host cell death, inducing lymphocyte exhaustion and depletion, and finally, mutation and escape from immunity. In addition, SARS-CoV-2 employs strategies to take advantage of host cell resources for its benefits, such as inhibiting the ubiquitin-proteasome system, hijacking mitochondria functions, and usage of enhancing antibodies. It may be anticipated that as the tradeoffs of adaptation progress, the virus destructive burden will gradually subside. Some evidence suggests that SARS-CoV-2 will become part of the human respiratory virome, as had occurred with other coronaviruses, and coevolve with its host.
Main Author: | Tosta,Eduardo |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Instituto Oswaldo Cruz, Ministério da Saúde
2021
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762021000100206 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The seven constitutive respiratory defense barriers against SARS-CoV-2 infection
by: Tosta,Eduardo
Published: (2021) -
Coronavirus (SARS-CoV-2): preventions, keys to diagnosis and treatment of SARS-CoV-2
by: Patel,Kuldeep Singh, et al.
Published: (2020) -
Structure of SARS-CoV-2
by: International Livestock Research Institute
Published: (2020-07-10) -
There is no "origin" to SARS-CoV-2
by: Frutos, Roger, et al. -
Human Leukocyte Transcriptional Response to SARS-CoV-2 Infection
by: Vieira,Sandra Elisabete, et al.
Published: (2020)