Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state
BACKGROUND The first dengue cases in Brazil with laboratory confirmation occurred in the northern region of the country, with the isolation of two serotypes, dengue virus 1 (DENV-1) and DENV-4. In Ceará, the introduction of DENV-4 was reported during a DENV-1 epidemic in 2011, with only two isolations. OBJECTIVES The aim of this study was to characterise the first DENV-4 epidemic in the state of Ceará, Brazil. METHODS The study population was composed of patients with suspected dengue that were reported to health care units from January to December 2012. The laboratory confirmation of infection was made by viral isolation, reverse transcription polymerase chain reaction (RT-PCR), AgNS1, immunohistochemistry and IgM enzyme-linked immunosorbent assay (ELISA). MAIN CONCLUSIONS In the study year, 72,211 suspected dengue cases were reported and 51,865 of these cases (71.8%) were confirmed to be positive. Co-circulation of three serotypes, DENV-1, DENV-3 and DENV-4, was detected with a predominance of DENV-4 (95.3%). Most cases were not severe, but there were 44 fatal outcomes. DENV-4 Genotype II was identified for the first time in Ceará.
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Instituto Oswaldo Cruz, Ministério da Saúde
2018
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oai:scielo:S0074-027620180011003002018-10-10Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the stateRamalho,Izabel Letícia CavalcanteAraújo,Fernanda Montenegro de CarvalhoCavalcanti,Luciano Pamplona de GóesBraga,Deborah Nunes MeloPerdigão,Anne Carolinne BezerraSantos,Flavia Barreto dosNogueira,Fernanda de BruyckerEscóssia,Kiliana Nogueira Farias daGuedes,Maria Izabel Florindo dengue 4 epidemiology deaths genotyping Ceará/Brazil BACKGROUND The first dengue cases in Brazil with laboratory confirmation occurred in the northern region of the country, with the isolation of two serotypes, dengue virus 1 (DENV-1) and DENV-4. In Ceará, the introduction of DENV-4 was reported during a DENV-1 epidemic in 2011, with only two isolations. OBJECTIVES The aim of this study was to characterise the first DENV-4 epidemic in the state of Ceará, Brazil. METHODS The study population was composed of patients with suspected dengue that were reported to health care units from January to December 2012. The laboratory confirmation of infection was made by viral isolation, reverse transcription polymerase chain reaction (RT-PCR), AgNS1, immunohistochemistry and IgM enzyme-linked immunosorbent assay (ELISA). MAIN CONCLUSIONS In the study year, 72,211 suspected dengue cases were reported and 51,865 of these cases (71.8%) were confirmed to be positive. Co-circulation of three serotypes, DENV-1, DENV-3 and DENV-4, was detected with a predominance of DENV-4 (95.3%). Most cases were not severe, but there were 44 fatal outcomes. DENV-4 Genotype II was identified for the first time in Ceará.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.113 n.11 20182018-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001100300en10.1590/0074-02760180320 |
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Ramalho,Izabel Letícia Cavalcante Araújo,Fernanda Montenegro de Carvalho Cavalcanti,Luciano Pamplona de Góes Braga,Deborah Nunes Melo Perdigão,Anne Carolinne Bezerra Santos,Flavia Barreto dos Nogueira,Fernanda de Bruycker Escóssia,Kiliana Nogueira Farias da Guedes,Maria Izabel Florindo |
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Ramalho,Izabel Letícia Cavalcante Araújo,Fernanda Montenegro de Carvalho Cavalcanti,Luciano Pamplona de Góes Braga,Deborah Nunes Melo Perdigão,Anne Carolinne Bezerra Santos,Flavia Barreto dos Nogueira,Fernanda de Bruycker Escóssia,Kiliana Nogueira Farias da Guedes,Maria Izabel Florindo Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
author_facet |
Ramalho,Izabel Letícia Cavalcante Araújo,Fernanda Montenegro de Carvalho Cavalcanti,Luciano Pamplona de Góes Braga,Deborah Nunes Melo Perdigão,Anne Carolinne Bezerra Santos,Flavia Barreto dos Nogueira,Fernanda de Bruycker Escóssia,Kiliana Nogueira Farias da Guedes,Maria Izabel Florindo |
author_sort |
Ramalho,Izabel Letícia Cavalcante |
title |
Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
title_short |
Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
title_full |
Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
title_fullStr |
Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
title_full_unstemmed |
Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
title_sort |
dengue 4 in ceará, brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
description |
BACKGROUND The first dengue cases in Brazil with laboratory confirmation occurred in the northern region of the country, with the isolation of two serotypes, dengue virus 1 (DENV-1) and DENV-4. In Ceará, the introduction of DENV-4 was reported during a DENV-1 epidemic in 2011, with only two isolations. OBJECTIVES The aim of this study was to characterise the first DENV-4 epidemic in the state of Ceará, Brazil. METHODS The study population was composed of patients with suspected dengue that were reported to health care units from January to December 2012. The laboratory confirmation of infection was made by viral isolation, reverse transcription polymerase chain reaction (RT-PCR), AgNS1, immunohistochemistry and IgM enzyme-linked immunosorbent assay (ELISA). MAIN CONCLUSIONS In the study year, 72,211 suspected dengue cases were reported and 51,865 of these cases (71.8%) were confirmed to be positive. Co-circulation of three serotypes, DENV-1, DENV-3 and DENV-4, was detected with a predominance of DENV-4 (95.3%). Most cases were not severe, but there were 44 fatal outcomes. DENV-4 Genotype II was identified for the first time in Ceará. |
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Instituto Oswaldo Cruz, Ministério da Saúde |
publishDate |
2018 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001100300 |
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