Cytotoxic activity in cutaneous leishmaniasis

Cytotoxic activity in cutaneous leishmaniasis

Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease.

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Main Authors: Campos,Taís M, Costa,Rúbia, Passos,Sara, Carvalho,Lucas P
Format: Digital revista
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2017
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001100733
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spelling oai:scielo:S0074-027620170011007332018-02-15Cytotoxic activity in cutaneous leishmaniasisCampos,Taís MCosta,RúbiaPassos,SaraCarvalho,Lucas P cytotoxicity CD8+ T cells NK cells cutaneous leishmaniasis immunopathology Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.112 n.11 20172017-11-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001100733en10.1590/0074-02760170109
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Campos,Taís M
Costa,Rúbia
Passos,Sara
Carvalho,Lucas P
spellingShingle Campos,Taís M
Costa,Rúbia
Passos,Sara
Carvalho,Lucas P
Cytotoxic activity in cutaneous leishmaniasis
author_facet Campos,Taís M
Costa,Rúbia
Passos,Sara
Carvalho,Lucas P
author_sort Campos,Taís M
title Cytotoxic activity in cutaneous leishmaniasis
title_short Cytotoxic activity in cutaneous leishmaniasis
title_full Cytotoxic activity in cutaneous leishmaniasis
title_fullStr Cytotoxic activity in cutaneous leishmaniasis
title_full_unstemmed Cytotoxic activity in cutaneous leishmaniasis
title_sort cytotoxic activity in cutaneous leishmaniasis
description Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease.
publisher Instituto Oswaldo Cruz, Ministério da Saúde
publishDate 2017
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001100733
work_keys_str_mv AT campostaism cytotoxicactivityincutaneousleishmaniasis
AT costarubia cytotoxicactivityincutaneousleishmaniasis
AT passossara cytotoxicactivityincutaneousleishmaniasis
AT carvalholucasp cytotoxicactivityincutaneousleishmaniasis
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