Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives
The definition of a biomarker provided by the World Health Organization is any substance, structure, or process that can be measured in the body, or its products and influence, or predict the incidence or outcome of disease. Currently, the lack of prognosis and progression markers for chronic Chagas disease has posed limitations for testing new drugs to treat this neglected disease. Several molecules and techniques to detect biomarkers inTrypanosoma cruzi-infected patients have been proposed to assess whether specific treatment with benznidazole or nifurtimox is effective. Isolated proteins or protein groups from different T. cruzistages and parasite-derived glycoproteins and synthetic neoglycoconjugates have been demonstrated to be useful for this purpose, as have nucleic acid amplification techniques. The amplification of T. cruziDNA using the real-time polymerase chain reaction method is the leading test for assessing responses to treatment in a short period of time. Biochemical biomarkers have been tested early after specific treatment. Cytokines and surface markers represent promising molecules for the characterisation of host cellular responses, but need to be further assessed.
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Instituto Oswaldo Cruz, Ministério da Saúde
2015
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oai:scielo:S0074-027620150003004222015-10-09Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectivesPinazo,Maria-JesusThomas,Maria-CarmenBustamante,JuanAlmeida,Igor Correia deLopez,Manuel-CarlosGascon,Joaquim biological marker Chagas disease Trypanosoma cruzi therapeutic response parasite marker host markers The definition of a biomarker provided by the World Health Organization is any substance, structure, or process that can be measured in the body, or its products and influence, or predict the incidence or outcome of disease. Currently, the lack of prognosis and progression markers for chronic Chagas disease has posed limitations for testing new drugs to treat this neglected disease. Several molecules and techniques to detect biomarkers inTrypanosoma cruzi-infected patients have been proposed to assess whether specific treatment with benznidazole or nifurtimox is effective. Isolated proteins or protein groups from different T. cruzistages and parasite-derived glycoproteins and synthetic neoglycoconjugates have been demonstrated to be useful for this purpose, as have nucleic acid amplification techniques. The amplification of T. cruziDNA using the real-time polymerase chain reaction method is the leading test for assessing responses to treatment in a short period of time. Biochemical biomarkers have been tested early after specific treatment. Cytokines and surface markers represent promising molecules for the characterisation of host cellular responses, but need to be further assessed.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.110 n.3 20152015-05-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000300422en10.1590/0074-02760140435 |
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Pinazo,Maria-Jesus Thomas,Maria-Carmen Bustamante,Juan Almeida,Igor Correia de Lopez,Manuel-Carlos Gascon,Joaquim |
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Pinazo,Maria-Jesus Thomas,Maria-Carmen Bustamante,Juan Almeida,Igor Correia de Lopez,Manuel-Carlos Gascon,Joaquim Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives |
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Pinazo,Maria-Jesus Thomas,Maria-Carmen Bustamante,Juan Almeida,Igor Correia de Lopez,Manuel-Carlos Gascon,Joaquim |
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Pinazo,Maria-Jesus |
title |
Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives |
title_short |
Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives |
title_full |
Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives |
title_fullStr |
Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives |
title_full_unstemmed |
Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives |
title_sort |
biomarkers of therapeutic responses in chronic chagas disease: state of the art and future perspectives |
description |
The definition of a biomarker provided by the World Health Organization is any substance, structure, or process that can be measured in the body, or its products and influence, or predict the incidence or outcome of disease. Currently, the lack of prognosis and progression markers for chronic Chagas disease has posed limitations for testing new drugs to treat this neglected disease. Several molecules and techniques to detect biomarkers inTrypanosoma cruzi-infected patients have been proposed to assess whether specific treatment with benznidazole or nifurtimox is effective. Isolated proteins or protein groups from different T. cruzistages and parasite-derived glycoproteins and synthetic neoglycoconjugates have been demonstrated to be useful for this purpose, as have nucleic acid amplification techniques. The amplification of T. cruziDNA using the real-time polymerase chain reaction method is the leading test for assessing responses to treatment in a short period of time. Biochemical biomarkers have been tested early after specific treatment. Cytokines and surface markers represent promising molecules for the characterisation of host cellular responses, but need to be further assessed. |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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2015 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000300422 |
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