Spontaneous hepatitis C viral clearance and hepatitis C chronic infection are associated with distinct cytokine profiles in Mexican patients
The mechanisms related to the spontaneous clearance of hepatitis C virus (HCV) have been primarily studied in regions where the infection is endemic. Results of prior studies have been extrapolated to populations with low endemicity, such as Mexico. Herein, we determined the cytokine profiles in serum samples from Mexican patients who spontaneously cleared HCV and patients chronically infected with HCV genotype 1a. Chronic HCV-infected patients displayed increased interleukin (IL)-8 and regulated upon activation, normal T-cell expressed and secreted (CCL-5) secretion, whereas patients who spontaneously cleared HCV showed augmented levels of IL-1 alpha, tumour necrosis factor-alpha, transforming growth factor-beta, monocyte chemoattractant protein-2 (CCL-8), IL-13 and IL-15. Our study suggeststhat cytokine profiles may predict disease outcome during HCV infection.
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Instituto Oswaldo Cruz, Ministério da Saúde
2015
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oai:scielo:S0074-027620150002002672015-10-09Spontaneous hepatitis C viral clearance and hepatitis C chronic infection are associated with distinct cytokine profiles in Mexican patientsFierro,Nora AGonzález-Aldaco,KarinaTorres-Valadez,RafaelTrujillo-Trujillo,Maria ERoman,SoniaTrujillo-Ochoa,Jorge LPanduro/,Arturo hepatitis C virus cytokines viral clearance genotype 1a The mechanisms related to the spontaneous clearance of hepatitis C virus (HCV) have been primarily studied in regions where the infection is endemic. Results of prior studies have been extrapolated to populations with low endemicity, such as Mexico. Herein, we determined the cytokine profiles in serum samples from Mexican patients who spontaneously cleared HCV and patients chronically infected with HCV genotype 1a. Chronic HCV-infected patients displayed increased interleukin (IL)-8 and regulated upon activation, normal T-cell expressed and secreted (CCL-5) secretion, whereas patients who spontaneously cleared HCV showed augmented levels of IL-1 alpha, tumour necrosis factor-alpha, transforming growth factor-beta, monocyte chemoattractant protein-2 (CCL-8), IL-13 and IL-15. Our study suggeststhat cytokine profiles may predict disease outcome during HCV infection.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.110 n.2 20152015-04-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200267en10.1590/0074-02760140377 |
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Fierro,Nora A González-Aldaco,Karina Torres-Valadez,Rafael Trujillo-Trujillo,Maria E Roman,Sonia Trujillo-Ochoa,Jorge L Panduro/,Arturo |
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Fierro,Nora A González-Aldaco,Karina Torres-Valadez,Rafael Trujillo-Trujillo,Maria E Roman,Sonia Trujillo-Ochoa,Jorge L Panduro/,Arturo Spontaneous hepatitis C viral clearance and hepatitis C chronic infection are associated with distinct cytokine profiles in Mexican patients |
author_facet |
Fierro,Nora A González-Aldaco,Karina Torres-Valadez,Rafael Trujillo-Trujillo,Maria E Roman,Sonia Trujillo-Ochoa,Jorge L Panduro/,Arturo |
author_sort |
Fierro,Nora A |
title |
Spontaneous hepatitis C viral clearance and hepatitis C chronic infection are associated with distinct cytokine profiles in Mexican patients |
title_short |
Spontaneous hepatitis C viral clearance and hepatitis C chronic infection are associated with distinct cytokine profiles in Mexican patients |
title_full |
Spontaneous hepatitis C viral clearance and hepatitis C chronic infection are associated with distinct cytokine profiles in Mexican patients |
title_fullStr |
Spontaneous hepatitis C viral clearance and hepatitis C chronic infection are associated with distinct cytokine profiles in Mexican patients |
title_full_unstemmed |
Spontaneous hepatitis C viral clearance and hepatitis C chronic infection are associated with distinct cytokine profiles in Mexican patients |
title_sort |
spontaneous hepatitis c viral clearance and hepatitis c chronic infection are associated with distinct cytokine profiles in mexican patients |
description |
The mechanisms related to the spontaneous clearance of hepatitis C virus (HCV) have been primarily studied in regions where the infection is endemic. Results of prior studies have been extrapolated to populations with low endemicity, such as Mexico. Herein, we determined the cytokine profiles in serum samples from Mexican patients who spontaneously cleared HCV and patients chronically infected with HCV genotype 1a. Chronic HCV-infected patients displayed increased interleukin (IL)-8 and regulated upon activation, normal T-cell expressed and secreted (CCL-5) secretion, whereas patients who spontaneously cleared HCV showed augmented levels of IL-1 alpha, tumour necrosis factor-alpha, transforming growth factor-beta, monocyte chemoattractant protein-2 (CCL-8), IL-13 and IL-15. Our study suggeststhat cytokine profiles may predict disease outcome during HCV infection. |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
publishDate |
2015 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200267 |
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