Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax isolates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world.
Saved in:
Main Authors: | Lizcano,Omaira Vera, Resende,Sarah Stela, Chehuan,Yonne F, Lacerda,Marcus VG, Brito,Cristiana FA, Zalis,Mariano G |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Instituto Oswaldo Cruz, Ministério da Saúde
2014
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700948 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Slow clearance of Plasmodium vivax with chloroquine amongst children younger than six months of age in the Brazilian Amazon
by: Siqueira,André M, et al.
Published: (2014) -
Assessment of chloroquine single dose treatment of malaria due to Plasmodium vivax in Brazilian Amazon
by: Pinto,Ana Yecê das Neves, et al.
Published: (2003) -
Plasmodium vivax resistance to chloroquine (R2) and mefloquine (R3) in Brazilian Amazon region
by: Alecrim,Maria das Graças C., et al.
Published: (1999) -
Emerging Plasmodium vivax resistance to chloroquine in South America: an overview
by: Gonçalves,Lígia Antunes, et al.
Published: (2014) -
Assessment of Therapeutic Response of Plasmodium vivax and Plasmodium falciparum to Chloroquine in a Malaria Transmission Free Area in Colombia
by: Castillo,Carmen Manuela, et al.
Published: (2002)