Outstanding insecurities concerning the use of an Ov16-based ELISA in the Amazonia onchocerciasis focus
In a recent issue of Memórias do Instituto Oswaldo Cruz, published in Rio de Janeiro in February 2014 (109: 87-92), Adami et al. have published a survey reporting Mansonella parasite prevalence in the Amazon Region. This report makes a useful contribution to the existing knowledge of filarial parasite distribution within the Amazon area, parasite prevalence rates in relation to age and occupation and provides observations on the possible clinical impact of Mansonella ozzardi. Their publication also provides an account of what appears to be a novel ELISA that has recently been used in the Simuliidae and Onchocerciasis Laboratory of the Oswaldo Cruz Institute, Rio de Janeiro, Brazil. We are concerned that the publication of this ELISA may have created an excessively positive impression of the effectiveness of the onchocerciasis recrudescence serological surveillance tools that are presently available for use in the Amazonia onchocerciasis focus. In this letter we have, thus, sought to highlight some of the limitations of this ELISA and suggest how continuing insecurities concerning the detection of antibodies to Onchocerca volvulus within the Amazonia onchocerciasis focus might be minimised.
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Instituto Oswaldo Cruz, Ministério da Saúde
2014
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oai:scielo:S0074-027620140004005062014-07-24Outstanding insecurities concerning the use of an Ov16-based ELISA in the Amazonia onchocerciasis focusLuz,Sérgio Luiz BessaCrainey,James LeeShelley,Anthony JohnRubio,Miguel Amazonia ELISA Ov16 onchocerciasis Mansonella ozzardi recrudescence In a recent issue of Memórias do Instituto Oswaldo Cruz, published in Rio de Janeiro in February 2014 (109: 87-92), Adami et al. have published a survey reporting Mansonella parasite prevalence in the Amazon Region. This report makes a useful contribution to the existing knowledge of filarial parasite distribution within the Amazon area, parasite prevalence rates in relation to age and occupation and provides observations on the possible clinical impact of Mansonella ozzardi. Their publication also provides an account of what appears to be a novel ELISA that has recently been used in the Simuliidae and Onchocerciasis Laboratory of the Oswaldo Cruz Institute, Rio de Janeiro, Brazil. We are concerned that the publication of this ELISA may have created an excessively positive impression of the effectiveness of the onchocerciasis recrudescence serological surveillance tools that are presently available for use in the Amazonia onchocerciasis focus. In this letter we have, thus, sought to highlight some of the limitations of this ELISA and suggest how continuing insecurities concerning the detection of antibodies to Onchocerca volvulus within the Amazonia onchocerciasis focus might be minimised.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.109 n.4 20142014-07-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000400506en10.1590/0074-0276140079 |
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Luz,Sérgio Luiz Bessa Crainey,James Lee Shelley,Anthony John Rubio,Miguel |
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Luz,Sérgio Luiz Bessa Crainey,James Lee Shelley,Anthony John Rubio,Miguel Outstanding insecurities concerning the use of an Ov16-based ELISA in the Amazonia onchocerciasis focus |
author_facet |
Luz,Sérgio Luiz Bessa Crainey,James Lee Shelley,Anthony John Rubio,Miguel |
author_sort |
Luz,Sérgio Luiz Bessa |
title |
Outstanding insecurities concerning the use of an Ov16-based ELISA in the Amazonia onchocerciasis focus |
title_short |
Outstanding insecurities concerning the use of an Ov16-based ELISA in the Amazonia onchocerciasis focus |
title_full |
Outstanding insecurities concerning the use of an Ov16-based ELISA in the Amazonia onchocerciasis focus |
title_fullStr |
Outstanding insecurities concerning the use of an Ov16-based ELISA in the Amazonia onchocerciasis focus |
title_full_unstemmed |
Outstanding insecurities concerning the use of an Ov16-based ELISA in the Amazonia onchocerciasis focus |
title_sort |
outstanding insecurities concerning the use of an ov16-based elisa in the amazonia onchocerciasis focus |
description |
In a recent issue of Memórias do Instituto Oswaldo Cruz, published in Rio de Janeiro in February 2014 (109: 87-92), Adami et al. have published a survey reporting Mansonella parasite prevalence in the Amazon Region. This report makes a useful contribution to the existing knowledge of filarial parasite distribution within the Amazon area, parasite prevalence rates in relation to age and occupation and provides observations on the possible clinical impact of Mansonella ozzardi. Their publication also provides an account of what appears to be a novel ELISA that has recently been used in the Simuliidae and Onchocerciasis Laboratory of the Oswaldo Cruz Institute, Rio de Janeiro, Brazil. We are concerned that the publication of this ELISA may have created an excessively positive impression of the effectiveness of the onchocerciasis recrudescence serological surveillance tools that are presently available for use in the Amazonia onchocerciasis focus. In this letter we have, thus, sought to highlight some of the limitations of this ELISA and suggest how continuing insecurities concerning the detection of antibodies to Onchocerca volvulus within the Amazonia onchocerciasis focus might be minimised. |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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2014 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000400506 |
work_keys_str_mv |
AT luzsergioluizbessa outstandinginsecuritiesconcerningtheuseofanov16basedelisaintheamazoniaonchocerciasisfocus AT craineyjameslee outstandinginsecuritiesconcerningtheuseofanov16basedelisaintheamazoniaonchocerciasisfocus AT shelleyanthonyjohn outstandinginsecuritiesconcerningtheuseofanov16basedelisaintheamazoniaonchocerciasisfocus AT rubiomiguel outstandinginsecuritiesconcerningtheuseofanov16basedelisaintheamazoniaonchocerciasisfocus |
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