Tissue distribution of residual antimony in rats treated with multiple doses of meglumine antimoniate
Meglumine antimoniate (MA) and sodium stibogluconate are pentavalent antimony (SbV) drugs used since the mid-1940s. Notwithstanding the fact that they are first-choice drugs for the treatment of leishmaniases, there are gaps in our knowledge of their toxicological profile, mode of action and kinetics. Little is known about the distribution of antimony in tissues after SbV administration. In this study, we evaluated the Sb content of tissues from male rats 24 h and three weeks after a 21-day course of treatment with MA (300 mg SbV/kg body wt/d, subcutaneous). Sb concentrations in the blood and organs were determined by inductively coupled plasma-mass spectrometry. In rats, as with in humans, the Sb blood levels after MA dosing can be described by a two-compartment model with a fast (t1/2 = 0.6 h) and a slow (t1/2 >> 24 h) elimination phase. The spleen was the organ that accumulated the highest amount of Sb, while bone and thyroid ranked second in descending order of tissues according to Sb levels (spleen >> bone, thyroid, kidneys > liver, epididymis, lungs, adrenals > prostate > thymus, pancreas, heart, small intestines > skeletal muscle, testes, stomach > brain). The pathophysiological consequences of Sb accumulation in the thyroid and Sb speciation in the liver, thyroid, spleen and bone warrant further studies.
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Instituto Oswaldo Cruz, Ministério da Saúde
2014
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oai:scielo:S0074-027620140004004202014-07-24Tissue distribution of residual antimony in rats treated with multiple doses of meglumine antimoniateCoelho,Deise RibaMiranda,Elaine SilvaSaint?Pierre,Tatiana DillenburgPaumgartten,Francisco José Roma pentavalent antimonials thyroid liver leishmaniases Glucantime pharmacokinetics Meglumine antimoniate (MA) and sodium stibogluconate are pentavalent antimony (SbV) drugs used since the mid-1940s. Notwithstanding the fact that they are first-choice drugs for the treatment of leishmaniases, there are gaps in our knowledge of their toxicological profile, mode of action and kinetics. Little is known about the distribution of antimony in tissues after SbV administration. In this study, we evaluated the Sb content of tissues from male rats 24 h and three weeks after a 21-day course of treatment with MA (300 mg SbV/kg body wt/d, subcutaneous). Sb concentrations in the blood and organs were determined by inductively coupled plasma-mass spectrometry. In rats, as with in humans, the Sb blood levels after MA dosing can be described by a two-compartment model with a fast (t1/2 = 0.6 h) and a slow (t1/2 >> 24 h) elimination phase. The spleen was the organ that accumulated the highest amount of Sb, while bone and thyroid ranked second in descending order of tissues according to Sb levels (spleen >> bone, thyroid, kidneys > liver, epididymis, lungs, adrenals > prostate > thymus, pancreas, heart, small intestines > skeletal muscle, testes, stomach > brain). The pathophysiological consequences of Sb accumulation in the thyroid and Sb speciation in the liver, thyroid, spleen and bone warrant further studies.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.109 n.4 20142014-07-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000400420en10.1590/0074-0276140030 |
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Coelho,Deise Riba Miranda,Elaine Silva Saint?Pierre,Tatiana Dillenburg Paumgartten,Francisco José Roma |
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Coelho,Deise Riba Miranda,Elaine Silva Saint?Pierre,Tatiana Dillenburg Paumgartten,Francisco José Roma Tissue distribution of residual antimony in rats treated with multiple doses of meglumine antimoniate |
author_facet |
Coelho,Deise Riba Miranda,Elaine Silva Saint?Pierre,Tatiana Dillenburg Paumgartten,Francisco José Roma |
author_sort |
Coelho,Deise Riba |
title |
Tissue distribution of residual antimony in rats treated with multiple doses of meglumine antimoniate |
title_short |
Tissue distribution of residual antimony in rats treated with multiple doses of meglumine antimoniate |
title_full |
Tissue distribution of residual antimony in rats treated with multiple doses of meglumine antimoniate |
title_fullStr |
Tissue distribution of residual antimony in rats treated with multiple doses of meglumine antimoniate |
title_full_unstemmed |
Tissue distribution of residual antimony in rats treated with multiple doses of meglumine antimoniate |
title_sort |
tissue distribution of residual antimony in rats treated with multiple doses of meglumine antimoniate |
description |
Meglumine antimoniate (MA) and sodium stibogluconate are pentavalent antimony (SbV) drugs used since the mid-1940s. Notwithstanding the fact that they are first-choice drugs for the treatment of leishmaniases, there are gaps in our knowledge of their toxicological profile, mode of action and kinetics. Little is known about the distribution of antimony in tissues after SbV administration. In this study, we evaluated the Sb content of tissues from male rats 24 h and three weeks after a 21-day course of treatment with MA (300 mg SbV/kg body wt/d, subcutaneous). Sb concentrations in the blood and organs were determined by inductively coupled plasma-mass spectrometry. In rats, as with in humans, the Sb blood levels after MA dosing can be described by a two-compartment model with a fast (t1/2 = 0.6 h) and a slow (t1/2 >> 24 h) elimination phase. The spleen was the organ that accumulated the highest amount of Sb, while bone and thyroid ranked second in descending order of tissues according to Sb levels (spleen >> bone, thyroid, kidneys > liver, epididymis, lungs, adrenals > prostate > thymus, pancreas, heart, small intestines > skeletal muscle, testes, stomach > brain). The pathophysiological consequences of Sb accumulation in the thyroid and Sb speciation in the liver, thyroid, spleen and bone warrant further studies. |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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2014 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000400420 |
work_keys_str_mv |
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