Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patients

Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patients

Immunocompromised patients may develop severe chronic anaemia when infected by human parvovirus B19 (B19V). However, this is not the case in human immunodeficiency virus (HIV)-infected patients with good adherence to highly active antiretroviral treatment (HAART). In this study, we investigated the clinical evolution of five HIV-infected patients receiving HAART who had B19V infections confirmed by serum polymerase chain reaction. Four of the patients were infected with genotype 1a strains and the remaining patient was infected with a genotype 3b strain. Anaemia was detected in three of the patients, but all patients recovered without requiring immunoglobulin and/or blood transfusions. In all cases, the attending physicians did not suspect the B19V infections. There was no apparent relationship between the infecting genotype and the clinical course. In the HAART era, B19V infections in HIV-positive patients may be limited, subtle or unapparent.

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Main Authors: Pereira,Renata Freire Alves, Garcia,Rita de Cássia Nasser Cubel, Azevedo,Kátia Martins Lopes de, Setúbal,Sérgio, Siqueira,Marilda Agudo Mendonça Teixeira de, Oliveira,Solange Artimos de
Format: Digital revista
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2014
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000200168
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spelling oai:scielo:S0074-027620140002001682015-02-24Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patientsPereira,Renata Freire AlvesGarcia,Rita de Cássia Nasser CubelAzevedo,Kátia Martins Lopes deSetúbal,SérgioSiqueira,Marilda Agudo Mendonça Teixeira deOliveira,Solange Artimos de HIV human parvovirus B19 seroconversion Immunocompromised patients may develop severe chronic anaemia when infected by human parvovirus B19 (B19V). However, this is not the case in human immunodeficiency virus (HIV)-infected patients with good adherence to highly active antiretroviral treatment (HAART). In this study, we investigated the clinical evolution of five HIV-infected patients receiving HAART who had B19V infections confirmed by serum polymerase chain reaction. Four of the patients were infected with genotype 1a strains and the remaining patient was infected with a genotype 3b strain. Anaemia was detected in three of the patients, but all patients recovered without requiring immunoglobulin and/or blood transfusions. In all cases, the attending physicians did not suspect the B19V infections. There was no apparent relationship between the infecting genotype and the clinical course. In the HAART era, B19V infections in HIV-positive patients may be limited, subtle or unapparent.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.109 n.2 20142014-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000200168en10.1590/0074-02760130312
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countrycode BR
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libraryname SciELO
language English
format Digital
author Pereira,Renata Freire Alves
Garcia,Rita de Cássia Nasser Cubel
Azevedo,Kátia Martins Lopes de
Setúbal,Sérgio
Siqueira,Marilda Agudo Mendonça Teixeira de
Oliveira,Solange Artimos de
spellingShingle Pereira,Renata Freire Alves
Garcia,Rita de Cássia Nasser Cubel
Azevedo,Kátia Martins Lopes de
Setúbal,Sérgio
Siqueira,Marilda Agudo Mendonça Teixeira de
Oliveira,Solange Artimos de
Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patients
author_facet Pereira,Renata Freire Alves
Garcia,Rita de Cássia Nasser Cubel
Azevedo,Kátia Martins Lopes de
Setúbal,Sérgio
Siqueira,Marilda Agudo Mendonça Teixeira de
Oliveira,Solange Artimos de
author_sort Pereira,Renata Freire Alves
title Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patients
title_short Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patients
title_full Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patients
title_fullStr Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patients
title_full_unstemmed Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patients
title_sort clinical features and laboratory findings of human parvovirus b19 in human immunodeficiency virus-infected patients
description Immunocompromised patients may develop severe chronic anaemia when infected by human parvovirus B19 (B19V). However, this is not the case in human immunodeficiency virus (HIV)-infected patients with good adherence to highly active antiretroviral treatment (HAART). In this study, we investigated the clinical evolution of five HIV-infected patients receiving HAART who had B19V infections confirmed by serum polymerase chain reaction. Four of the patients were infected with genotype 1a strains and the remaining patient was infected with a genotype 3b strain. Anaemia was detected in three of the patients, but all patients recovered without requiring immunoglobulin and/or blood transfusions. In all cases, the attending physicians did not suspect the B19V infections. There was no apparent relationship between the infecting genotype and the clinical course. In the HAART era, B19V infections in HIV-positive patients may be limited, subtle or unapparent.
publisher Instituto Oswaldo Cruz, Ministério da Saúde
publishDate 2014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000200168
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