Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts
Contact surveillance is a valuable strategy for controlling leprosy. A dynamic cohort study of leprosy contacts was initiated in 1987 at Oswaldo Cruz Foundation. The objective of this work was to review the data on the major risk factors leading up to the infectious stage of the disease, estimate incidence rates of leprosy in the cohort and characterise the risk factors for the disease among the contacts under surveillance. The incidence rate of leprosy among contacts of leprosy patients was estimated at 0.01694 cases per person-year in the first five years of follow-up. The following factors were associated with acquiring the disease: (i) not receiving the BCG vaccine, (ii) a negative Mitsuda reaction and (iii) contact with a patient with a multibacillary clinical form of leprosy. The contacts of index patients who had high bacilloscopic index scores > 1 were at especially high risk of infection. The following factors were associated with infection, which was defined as a seropositive reaction for anti-phenolic glicolipid-1 IgM: (i) young age (< 20 years), (ii) a low measured Mitsuda reaction (< 5 mm) and (iii) contact with an index patient who had a high bacilloscopic index. BCG vaccination and re-vaccination were shown to be protective among household contacts. The main conclusions of this study indicate an urgent need for additional leprosy control strategies in areas with a high incidence of the disease.
Main Authors: | , , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Instituto Oswaldo Cruz, Ministério da Saúde
2012
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000800015 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S0074-02762012000800015 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S0074-027620120008000152013-01-03Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contactsSarno,Euzenir NunesDuppre,Nadia CristinaSales,Anna MariaHacker,Mariana AndréaNery,José AugustoMatos,Haroldo José de leprosy contact surveillance epidemiology PGL-1 Contact surveillance is a valuable strategy for controlling leprosy. A dynamic cohort study of leprosy contacts was initiated in 1987 at Oswaldo Cruz Foundation. The objective of this work was to review the data on the major risk factors leading up to the infectious stage of the disease, estimate incidence rates of leprosy in the cohort and characterise the risk factors for the disease among the contacts under surveillance. The incidence rate of leprosy among contacts of leprosy patients was estimated at 0.01694 cases per person-year in the first five years of follow-up. The following factors were associated with acquiring the disease: (i) not receiving the BCG vaccine, (ii) a negative Mitsuda reaction and (iii) contact with a patient with a multibacillary clinical form of leprosy. The contacts of index patients who had high bacilloscopic index scores > 1 were at especially high risk of infection. The following factors were associated with infection, which was defined as a seropositive reaction for anti-phenolic glicolipid-1 IgM: (i) young age (< 20 years), (ii) a low measured Mitsuda reaction (< 5 mm) and (iii) contact with an index patient who had a high bacilloscopic index. BCG vaccination and re-vaccination were shown to be protective among household contacts. The main conclusions of this study indicate an urgent need for additional leprosy control strategies in areas with a high incidence of the disease.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.107 n.8 20122012-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000800015en10.1590/S0074-02762012000800015 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Sarno,Euzenir Nunes Duppre,Nadia Cristina Sales,Anna Maria Hacker,Mariana Andréa Nery,José Augusto Matos,Haroldo José de |
spellingShingle |
Sarno,Euzenir Nunes Duppre,Nadia Cristina Sales,Anna Maria Hacker,Mariana Andréa Nery,José Augusto Matos,Haroldo José de Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts |
author_facet |
Sarno,Euzenir Nunes Duppre,Nadia Cristina Sales,Anna Maria Hacker,Mariana Andréa Nery,José Augusto Matos,Haroldo José de |
author_sort |
Sarno,Euzenir Nunes |
title |
Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts |
title_short |
Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts |
title_full |
Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts |
title_fullStr |
Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts |
title_full_unstemmed |
Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts |
title_sort |
leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts |
description |
Contact surveillance is a valuable strategy for controlling leprosy. A dynamic cohort study of leprosy contacts was initiated in 1987 at Oswaldo Cruz Foundation. The objective of this work was to review the data on the major risk factors leading up to the infectious stage of the disease, estimate incidence rates of leprosy in the cohort and characterise the risk factors for the disease among the contacts under surveillance. The incidence rate of leprosy among contacts of leprosy patients was estimated at 0.01694 cases per person-year in the first five years of follow-up. The following factors were associated with acquiring the disease: (i) not receiving the BCG vaccine, (ii) a negative Mitsuda reaction and (iii) contact with a patient with a multibacillary clinical form of leprosy. The contacts of index patients who had high bacilloscopic index scores > 1 were at especially high risk of infection. The following factors were associated with infection, which was defined as a seropositive reaction for anti-phenolic glicolipid-1 IgM: (i) young age (< 20 years), (ii) a low measured Mitsuda reaction (< 5 mm) and (iii) contact with an index patient who had a high bacilloscopic index. BCG vaccination and re-vaccination were shown to be protective among household contacts. The main conclusions of this study indicate an urgent need for additional leprosy control strategies in areas with a high incidence of the disease. |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
publishDate |
2012 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000800015 |
work_keys_str_mv |
AT sarnoeuzenirnunes leprosyexposureinfectionanddiseasea25yearsurveillancestudyofleprosypatientcontacts AT dupprenadiacristina leprosyexposureinfectionanddiseasea25yearsurveillancestudyofleprosypatientcontacts AT salesannamaria leprosyexposureinfectionanddiseasea25yearsurveillancestudyofleprosypatientcontacts AT hackermarianaandrea leprosyexposureinfectionanddiseasea25yearsurveillancestudyofleprosypatientcontacts AT neryjoseaugusto leprosyexposureinfectionanddiseasea25yearsurveillancestudyofleprosypatientcontacts AT matosharoldojosede leprosyexposureinfectionanddiseasea25yearsurveillancestudyofleprosypatientcontacts |
_version_ |
1756383734569893888 |