Hepatitis C virus quantification in serum and saliva of HCV-infected patients

Hepatitis C virus quantification in serum and saliva of HCV-infected patients

The hepatitis C virus (HCV) can be detected in blood and other bodily fluids, such as saliva, semen and gastric juices. The aim of this study was to compare the HCV viral loads in the serum and saliva of infected patients. Twenty-nine patients with detectable HCV RNA in their serum and saliva were included in this study. The HCV viral loads were determined through quantitative real-time polymerase chain reactions. The median viral RNA levels were 5.78 log10 copies in the serum and 3.32 log10 copies in the saliva. We observed that the salivary HCV viral load was significantly lower than the viral load in the serum. Further studies are required to understand the role of saliva in the diagnosis, management and potential transmission of HCV.

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Main Authors: Menezes,Gisele Barreto Lopes, Pereira,Fernanda Albuquerque, Duarte,César Augusto Barros, Carmo,Theomira Mauadie Azevedo, Silva Filho,Hermes Pedreira da, Zarife,Maria Alice, Krieger,Marco Aurélio, Reis,Eliana Almeida Gomes, Reis,Mitermayer G
Format: Digital revista
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2012
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000500016
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spelling oai:scielo:S0074-027620120005000162012-07-26Hepatitis C virus quantification in serum and saliva of HCV-infected patientsMenezes,Gisele Barreto LopesPereira,Fernanda AlbuquerqueDuarte,César Augusto BarrosCarmo,Theomira Mauadie AzevedoSilva Filho,Hermes Pedreira daZarife,Maria AliceKrieger,Marco AurélioReis,Eliana Almeida GomesReis,Mitermayer G HCV HCV transmission serum HCV load salivary HCV load The hepatitis C virus (HCV) can be detected in blood and other bodily fluids, such as saliva, semen and gastric juices. The aim of this study was to compare the HCV viral loads in the serum and saliva of infected patients. Twenty-nine patients with detectable HCV RNA in their serum and saliva were included in this study. The HCV viral loads were determined through quantitative real-time polymerase chain reactions. The median viral RNA levels were 5.78 log10 copies in the serum and 3.32 log10 copies in the saliva. We observed that the salivary HCV viral load was significantly lower than the viral load in the serum. Further studies are required to understand the role of saliva in the diagnosis, management and potential transmission of HCV.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.107 n.5 20122012-08-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000500016en10.1590/S0074-02762012000500016
institution SCIELO
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country Brasil
countrycode BR
component Revista
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databasecode rev-scielo-br
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region America del Sur
libraryname SciELO
language English
format Digital
author Menezes,Gisele Barreto Lopes
Pereira,Fernanda Albuquerque
Duarte,César Augusto Barros
Carmo,Theomira Mauadie Azevedo
Silva Filho,Hermes Pedreira da
Zarife,Maria Alice
Krieger,Marco Aurélio
Reis,Eliana Almeida Gomes
Reis,Mitermayer G
spellingShingle Menezes,Gisele Barreto Lopes
Pereira,Fernanda Albuquerque
Duarte,César Augusto Barros
Carmo,Theomira Mauadie Azevedo
Silva Filho,Hermes Pedreira da
Zarife,Maria Alice
Krieger,Marco Aurélio
Reis,Eliana Almeida Gomes
Reis,Mitermayer G
Hepatitis C virus quantification in serum and saliva of HCV-infected patients
author_facet Menezes,Gisele Barreto Lopes
Pereira,Fernanda Albuquerque
Duarte,César Augusto Barros
Carmo,Theomira Mauadie Azevedo
Silva Filho,Hermes Pedreira da
Zarife,Maria Alice
Krieger,Marco Aurélio
Reis,Eliana Almeida Gomes
Reis,Mitermayer G
author_sort Menezes,Gisele Barreto Lopes
title Hepatitis C virus quantification in serum and saliva of HCV-infected patients
title_short Hepatitis C virus quantification in serum and saliva of HCV-infected patients
title_full Hepatitis C virus quantification in serum and saliva of HCV-infected patients
title_fullStr Hepatitis C virus quantification in serum and saliva of HCV-infected patients
title_full_unstemmed Hepatitis C virus quantification in serum and saliva of HCV-infected patients
title_sort hepatitis c virus quantification in serum and saliva of hcv-infected patients
description The hepatitis C virus (HCV) can be detected in blood and other bodily fluids, such as saliva, semen and gastric juices. The aim of this study was to compare the HCV viral loads in the serum and saliva of infected patients. Twenty-nine patients with detectable HCV RNA in their serum and saliva were included in this study. The HCV viral loads were determined through quantitative real-time polymerase chain reactions. The median viral RNA levels were 5.78 log10 copies in the serum and 3.32 log10 copies in the saliva. We observed that the salivary HCV viral load was significantly lower than the viral load in the serum. Further studies are required to understand the role of saliva in the diagnosis, management and potential transmission of HCV.
publisher Instituto Oswaldo Cruz, Ministério da Saúde
publishDate 2012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000500016
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