Hepatitis C virus quantification in serum and saliva of HCV-infected patients
The hepatitis C virus (HCV) can be detected in blood and other bodily fluids, such as saliva, semen and gastric juices. The aim of this study was to compare the HCV viral loads in the serum and saliva of infected patients. Twenty-nine patients with detectable HCV RNA in their serum and saliva were included in this study. The HCV viral loads were determined through quantitative real-time polymerase chain reactions. The median viral RNA levels were 5.78 log10 copies in the serum and 3.32 log10 copies in the saliva. We observed that the salivary HCV viral load was significantly lower than the viral load in the serum. Further studies are required to understand the role of saliva in the diagnosis, management and potential transmission of HCV.
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Instituto Oswaldo Cruz, Ministério da Saúde
2012
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oai:scielo:S0074-027620120005000162012-07-26Hepatitis C virus quantification in serum and saliva of HCV-infected patientsMenezes,Gisele Barreto LopesPereira,Fernanda AlbuquerqueDuarte,César Augusto BarrosCarmo,Theomira Mauadie AzevedoSilva Filho,Hermes Pedreira daZarife,Maria AliceKrieger,Marco AurélioReis,Eliana Almeida GomesReis,Mitermayer G HCV HCV transmission serum HCV load salivary HCV load The hepatitis C virus (HCV) can be detected in blood and other bodily fluids, such as saliva, semen and gastric juices. The aim of this study was to compare the HCV viral loads in the serum and saliva of infected patients. Twenty-nine patients with detectable HCV RNA in their serum and saliva were included in this study. The HCV viral loads were determined through quantitative real-time polymerase chain reactions. The median viral RNA levels were 5.78 log10 copies in the serum and 3.32 log10 copies in the saliva. We observed that the salivary HCV viral load was significantly lower than the viral load in the serum. Further studies are required to understand the role of saliva in the diagnosis, management and potential transmission of HCV.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.107 n.5 20122012-08-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000500016en10.1590/S0074-02762012000500016 |
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Menezes,Gisele Barreto Lopes Pereira,Fernanda Albuquerque Duarte,César Augusto Barros Carmo,Theomira Mauadie Azevedo Silva Filho,Hermes Pedreira da Zarife,Maria Alice Krieger,Marco Aurélio Reis,Eliana Almeida Gomes Reis,Mitermayer G |
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Menezes,Gisele Barreto Lopes Pereira,Fernanda Albuquerque Duarte,César Augusto Barros Carmo,Theomira Mauadie Azevedo Silva Filho,Hermes Pedreira da Zarife,Maria Alice Krieger,Marco Aurélio Reis,Eliana Almeida Gomes Reis,Mitermayer G Hepatitis C virus quantification in serum and saliva of HCV-infected patients |
author_facet |
Menezes,Gisele Barreto Lopes Pereira,Fernanda Albuquerque Duarte,César Augusto Barros Carmo,Theomira Mauadie Azevedo Silva Filho,Hermes Pedreira da Zarife,Maria Alice Krieger,Marco Aurélio Reis,Eliana Almeida Gomes Reis,Mitermayer G |
author_sort |
Menezes,Gisele Barreto Lopes |
title |
Hepatitis C virus quantification in serum and saliva of HCV-infected patients |
title_short |
Hepatitis C virus quantification in serum and saliva of HCV-infected patients |
title_full |
Hepatitis C virus quantification in serum and saliva of HCV-infected patients |
title_fullStr |
Hepatitis C virus quantification in serum and saliva of HCV-infected patients |
title_full_unstemmed |
Hepatitis C virus quantification in serum and saliva of HCV-infected patients |
title_sort |
hepatitis c virus quantification in serum and saliva of hcv-infected patients |
description |
The hepatitis C virus (HCV) can be detected in blood and other bodily fluids, such as saliva, semen and gastric juices. The aim of this study was to compare the HCV viral loads in the serum and saliva of infected patients. Twenty-nine patients with detectable HCV RNA in their serum and saliva were included in this study. The HCV viral loads were determined through quantitative real-time polymerase chain reactions. The median viral RNA levels were 5.78 log10 copies in the serum and 3.32 log10 copies in the saliva. We observed that the salivary HCV viral load was significantly lower than the viral load in the serum. Further studies are required to understand the role of saliva in the diagnosis, management and potential transmission of HCV. |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
publishDate |
2012 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000500016 |
work_keys_str_mv |
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