The presence of Helicobacter pylori in the liver depends on the Th1, Th17 and Treg cytokine profile of the patient
The hypothesis that Helicobactermight be a risk factor for human liver diseases has arisen after the detection of Helicobacter DNA in hepatic tissue of patients with hepatobiliary diseases. Nevertheless, no explanation that justifies the presence of the bacterium in the human liver has been proposed. We evaluated the presence of Helicobacterin the liver of patients with hepatic diseases of different aetiologies. We prospectively evaluated 147 patients (106 with primary hepatic diseases and 41 with hepatic metastatic tumours) and 20 liver donors as controls. Helicobacter species were investigated in the liver by culture and specific 16S rDNA nested-polymerase chain reaction followed by sequencing. Serum and hepatic levels of representative cytokines of T regulatory cell, T helper (Th)1 and Th17 cell lineages were determined using enzyme linked immunosorbent assay. The data were evaluated using logistic models. Detection of Helicobacter pylori DNA in the liver was independently associated with hepatitis B virus/hepatitis C virus, pancreatic carcinoma and a cytokine pattern characterised by high interleukin (IL)-10, low/absent interferon-γ and decreased IL-17A concentrations (p < 10-3). The bacterial DNA was never detected in the liver of patients with alcoholic cirrhosis and autoimmune hepatitis that are associated with Th1/Th17 polarisation. H. pylori may be observed in the liver of patients with certain hepatic and pancreatic diseases, but this might depend on the patient cytokine profile.
Main Authors: | Silva,Luciana Diniz, Rocha,Andreia Maria Camargos, Rocha,Gifone Aguiar, Moura,Sílvia Beleza de, Rocha,Márcia Maria Negreiros Pinto, Dani,Renato, Melo,Fabrício Freire de, Guerra,Juliana Becattini, Castro,Lúcia Porto Fonseca de, Mendes,Guilherme Santiago, Ferrari,Teresa Cristina de Abreu, Lima,Agnaldo Soares, Queiroz,Dulciene Maria Magalhães |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Instituto Oswaldo Cruz, Ministério da Saúde
2011
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000600016 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Helicobacter pylori transiently in the mouth may participate in the transmission of infection
by: Silva,Denise G, et al.
Published: (2010) -
Cytokines and chemokines associated with Treg/Th17 response in chronic inflammatory periapical disease
by: TOLEDO,André Oliveira Naufel de, et al.
Published: (2019) -
Benznidazole affects expression of Th1, Th17 and Treg cytokines during acute experimental Trypanosoma cruzi infection
by: Gatto,Mariana, et al.
Published: (2017) -
Immunoblotting for the serodiagnosis of Helicobacter pylori infection in Brazilian patients with and without gastric carcinoma
by: Rocha,Andreia MC, et al.
Published: (2004) -
Úlcera péptica gastroduodenal e infecção pelo Helicobacter pylori na criança e adolescente
by: Bittencourt,Paulo F. S., et al.
Published: (2006)