Laboratorial atopy markers in children with human immunodeficiency virus

Changes in immune system functions are one of the most important consequences of human immunodeficiency virus (HIV) infection. Studies have reported a higher prevalence of disease mediated by immunological hypersensitivity mechanisms in HIV-positive patients. This study aims to observe how immunological changes in HIV-infected children interfere in atopy determinants. Fifty-seven HIV-positive children were studied between June 2004-August 2005 to evaluate the possible modifications in atopy diagnosis from prick test environmental allergen reactivity. Patients were subjected to two evaluations: on both occasions, atopic and non-atopic groups were correlated with immunological (CD4+ and CD8+ lymphocyte concentrations and serum levels of IgA, IgM, IgG and IgE) and viral parameters (HIV viral load). The percent atopy was 20.05 in the first and 29.82 in the second evaluation and atopy was diagnosed in patients without immunosuppression or with moderate immunosuppression. Six patients changed from a negative to a positive atopy profile. One patient with a decreased CD4+ T lymphocyte concentration failed to demonstrate prick test positivity between evaluations. Multivariate analysis showed that the variables associated with atopy diagnosis included a personal history of allergic diseases as well as elevated IgE for age and elevated IgE levels. Atopy development in HIV-infected children seems to be modulated by genetic and environmental factors as well as immunological condition.

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Main Authors: Cruz,Cristina Rodrigues, Carvalho,Vania Oliveira, Santos,Rosaly Vieira, Tahan,Tony Tannous, Rossoni,Andrea Maciel Oliveira, Lima,Hermenio Cavalcante
Format: Digital revista
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2010
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000300008
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spelling oai:scielo:S0074-027620100003000082010-05-21Laboratorial atopy markers in children with human immunodeficiency virusCruz,Cristina RodriguesCarvalho,Vania OliveiraSantos,Rosaly VieiraTahan,Tony TannousRossoni,Andrea Maciel OliveiraLima,Hermenio Cavalcante HIV child immunoglobulin E allergy Changes in immune system functions are one of the most important consequences of human immunodeficiency virus (HIV) infection. Studies have reported a higher prevalence of disease mediated by immunological hypersensitivity mechanisms in HIV-positive patients. This study aims to observe how immunological changes in HIV-infected children interfere in atopy determinants. Fifty-seven HIV-positive children were studied between June 2004-August 2005 to evaluate the possible modifications in atopy diagnosis from prick test environmental allergen reactivity. Patients were subjected to two evaluations: on both occasions, atopic and non-atopic groups were correlated with immunological (CD4+ and CD8+ lymphocyte concentrations and serum levels of IgA, IgM, IgG and IgE) and viral parameters (HIV viral load). The percent atopy was 20.05 in the first and 29.82 in the second evaluation and atopy was diagnosed in patients without immunosuppression or with moderate immunosuppression. Six patients changed from a negative to a positive atopy profile. One patient with a decreased CD4+ T lymphocyte concentration failed to demonstrate prick test positivity between evaluations. Multivariate analysis showed that the variables associated with atopy diagnosis included a personal history of allergic diseases as well as elevated IgE for age and elevated IgE levels. Atopy development in HIV-infected children seems to be modulated by genetic and environmental factors as well as immunological condition.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.105 n.3 20102010-05-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000300008en10.1590/S0074-02762010000300008
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libraryname SciELO
language English
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author Cruz,Cristina Rodrigues
Carvalho,Vania Oliveira
Santos,Rosaly Vieira
Tahan,Tony Tannous
Rossoni,Andrea Maciel Oliveira
Lima,Hermenio Cavalcante
spellingShingle Cruz,Cristina Rodrigues
Carvalho,Vania Oliveira
Santos,Rosaly Vieira
Tahan,Tony Tannous
Rossoni,Andrea Maciel Oliveira
Lima,Hermenio Cavalcante
Laboratorial atopy markers in children with human immunodeficiency virus
author_facet Cruz,Cristina Rodrigues
Carvalho,Vania Oliveira
Santos,Rosaly Vieira
Tahan,Tony Tannous
Rossoni,Andrea Maciel Oliveira
Lima,Hermenio Cavalcante
author_sort Cruz,Cristina Rodrigues
title Laboratorial atopy markers in children with human immunodeficiency virus
title_short Laboratorial atopy markers in children with human immunodeficiency virus
title_full Laboratorial atopy markers in children with human immunodeficiency virus
title_fullStr Laboratorial atopy markers in children with human immunodeficiency virus
title_full_unstemmed Laboratorial atopy markers in children with human immunodeficiency virus
title_sort laboratorial atopy markers in children with human immunodeficiency virus
description Changes in immune system functions are one of the most important consequences of human immunodeficiency virus (HIV) infection. Studies have reported a higher prevalence of disease mediated by immunological hypersensitivity mechanisms in HIV-positive patients. This study aims to observe how immunological changes in HIV-infected children interfere in atopy determinants. Fifty-seven HIV-positive children were studied between June 2004-August 2005 to evaluate the possible modifications in atopy diagnosis from prick test environmental allergen reactivity. Patients were subjected to two evaluations: on both occasions, atopic and non-atopic groups were correlated with immunological (CD4+ and CD8+ lymphocyte concentrations and serum levels of IgA, IgM, IgG and IgE) and viral parameters (HIV viral load). The percent atopy was 20.05 in the first and 29.82 in the second evaluation and atopy was diagnosed in patients without immunosuppression or with moderate immunosuppression. Six patients changed from a negative to a positive atopy profile. One patient with a decreased CD4+ T lymphocyte concentration failed to demonstrate prick test positivity between evaluations. Multivariate analysis showed that the variables associated with atopy diagnosis included a personal history of allergic diseases as well as elevated IgE for age and elevated IgE levels. Atopy development in HIV-infected children seems to be modulated by genetic and environmental factors as well as immunological condition.
publisher Instituto Oswaldo Cruz, Ministério da Saúde
publishDate 2010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000300008
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