In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
The in vitro activity of four 2-nitropropene derivatives, 1-(3-benzothienyl)-2-nitropropene (N1), 1-(3-thienyl)-2-nitropropene (N2), 1-(5-bromo-2-thienyl)-2-nitropropene (N3) and 1-(4-bromo-2-thienyl)-2-nitropropene (N4), were tested against cultures of the parasite Trypanosoma cruzi. Cytotoxicity studies were performed using Vero cells. The blood trypomastigotes, amastigotes and epimastigotes showed differential degrees of sensitivity towards the four tested compounds; the highest activity against the epimastigotes and blood tripomastigotes was exhibited by N1, followed by N3, N4 and finally N2. In contrast, whereas the compounds N1, N3 and N4 exerted similar magnitudes of activity against amastigotes, N2 was found to be a much less potent compound. According to our results, the compound N1 had the highest level of activity (IC50: 0.6 μM) against epimastigotes.
Main Authors: | Herrera,Cristina, Vallejos,Gabriel A, Loaiza,Randall, Zeledón,Rodrigo, Urbina,Andrea, Sepúlveda-Boza,Silvia |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Instituto Oswaldo Cruz, Ministério da Saúde
2009
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000700007 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
In vitro activity of Etanidazole against the protozoan parasite Trypanosoma cruzi
by: Petray,Patricia B, et al.
Published: (2004) -
In vitro evaluation of the activity of aromatic nitrocompounds against Trypanosoma cruzi
by: Oliveira,Renata B, et al.
Published: (2003) -
In vitro activity and mutagenicity of bisbenzylisoquinolines and quinones against Trypanosoma cruzi Tripomastigotes
by: Rojas de Arias, A, et al.
Published: (1994) -
Differential in vitro activity of the DNA topoisomerase inhibitor idarubicin against Trypanosoma rangeli and Trypanosoma cruzi
by: Jobe,Momodou, et al.
Published: (2012) -
Antiparasitic Activity of Diterpenoids Against Trypanosoma cruzi
by: Alegre-Gómez, Sergio, et al.
Published: (2016-09-06)