Effectiveness and safety of isoniazid chemoprophylaxis for HIV-1 infected patients from Rio de Janeiro
The clinical and epidemiological characteristics, adverse events, treatment adherence and effectiveness of isoniazid chemoprophylaxis were analyzed in a cohort of 138 tuberculosis/HIV-coinfected patients. An open, non-randomized, pragmatic prophylactic trial was conducted on adult patients with a normal chest X-ray and positive tuberculin skin test (> 5 mm) who received isoniazid chemoprophylaxis (300 mg/day) for six months. The mean of follow up was 2.8 years (SD 1.3). Adherence to chemoprophylaxis was 87.7% (121/138). Only one patient presented tuberculosis after the end of chemoprophylaxis, corresponding to 0.3 cases per 100 persons per year. The relative risk of some adverse effects was 4.6 times higher (95% CI: 1.9-11.5) in patients with positive anti-HCV serology (4/9, 44.4%) compared to those with negative serology (12/129, 9.6%) (p = 0.002). This study provides evidence regarding the effectiveness and safety of a short and self-administered isoniazid regimen. We recommend the implementation of this routine by health service practitioners.
Main Authors: | Souza,Claudia Teresa Vieira de, Hökerberg,Yara Hahr Marques, Pacheco,Sandro Javier Bedoya, Rolla,Valéria Cavalcanti, Passos,Sonia Regina Lambert |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Instituto Oswaldo Cruz, Ministério da Saúde
2009
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000300011 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Isoniazid preventive therapy in HIV-infected and -uninfected children (0 - 14 years)
by: Schaaf,H S, et al.
Published: (2013) -
Validade dimensional do instrumento de qualidade de vida WHOQOL-BREF aplicado a trabalhadores de saúde
by: Castro,Marcelle Maria Lobo Dinis, et al.
Published: (2013) -
Clinical profile of dengue in the elderly using surveillance data from two epidemics
by: Hökerberg,Yara Hahr Marques, et al.
Published: (2022) -
Severe infection in patients with rheumatoid arthritis taking anakinra, rituximab, or abatacept: a systematic review of observational studies
by: Cabral,Vanderlea Poeys, et al.
Published: (2016) -
Cutaneous tuberculosis and HIV infection at a referral centre in Rio de Janeiro, Brazil
by: Mann,Danielle, et al.
Published: (2018)